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Highlights d TRPV cation channels are required for glucose starvationinduced AMPK activation d FBP-unoccupied aldolase inhibits Ca 2+ release of TRPVs at the ER-lysosome contact d The decrease of the local Ca 2+ allow TRPV proteins to interact with v-ATPase

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Many insects metamorphose from antagonistic larvae into mutualistic adult pollinators, with reciprocal adaptation leading to specialized insect-plant associations.It remains unknown how such interactions are established at molecular level. Here we assembled high-quality genomes of a fig species, Ficus pumila var. pumila, and its specific pollinating wasp, Wiebesia pumilae. We combined multi-omics with validation experiments to reveal molecular mechanisms underlying this specialized interaction. In the plant, we identified the specific compound attracting pollinators and validated the function of several key genes regulating its biosynthesis. In the pollinator, we found a highly reduced number of odorant-binding protein (OBP) genes and an OBP mainly binding the attractant. During antagonistic interaction, we found similar chemical profiles and turnovers throughout the development of galled ovules and seeds, and a significant contraction of detoxification-related gene families in the pollinator. Our study detects some key genes bridging coevolved mutualists, establishing expectations for more diffuse insect-pollinator systems.

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