Two novel polycyclic
polyprenylated acylphloroglucinols (PPAPs),
garcibractinones A (1) and B (2), as well
as three known analogues doitunggarcinones A–B (3–4) and garcibracteatone (5) were
isolated from Garcinia bracteata fruits.
Their structures were elucidated by comprehensive spectroscopic methods
and single crystal X-ray diffraction. Compounds 1 and 2 possess an unprecedented caged tricyclo-[4.4.1.11,4] dodecane skeleton, and their biosynthetic pathways are also proposed.
Compounds 1–2 were tested for their
inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide
(NO) production in RAW 264.7 macrophages.
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