Although many methods have been developed to create porous structures within polyelectrolyte films, it remains a challenge to conveniently define the spatial distribution of these structures. Herein, a simple, universal strategy with a high flexibility in programming porous regions throughout polyelectrolyte films is reported. This strategy is performed with the aid of laser scanning and the emergence of porous regions precisely tails after the moving path of laser beams. Quite different from previous strategies, the pore‐forming mechanism relies on laser‐triggered generation of gas to foam the films, which can be regulated by the content of photo‐sensitive groups, the intensity of laser beams, and the supramolecular interactions between polyelectrolyte chains. A prerequisite to succeed the foaming of polyelectrolyte films is to irradiate them under water, where the mobility of polyelectrolytes is activated to accommodate the pore formation within the films. Although many pore‐forming mechanisms involve aqueous systems, the porous structures here can be well preserved during drying procedures, which is hardly realized for conventional methods due to the formation of capillary pressure. The resulting polyelectrolyte films with patterned porosity can be quite useful in many fields, including but not limited to information display, surface wettability, and cell behavior manipulation.
Macroporous structures can be developed within polyelectrolyte multilayer films for efficient drug loading, but these structures tend to collapse or fracture during conventional drying procedures. Herein, a facile dehydrating method for macroporous polyelectrolyte multilayer films is proposed using solvent exchange to ethanol and then spontaneous evaporation. During these processes, the collapse of the macroporous structures can be effectively avoided, which can be ascribed to a combined effect of two factors. On one hand, capillary pressure during ethanol evaporation is relatively small since the surface tension of ethanol is much lower than that of water. On the other hand, solvent exchange suppresses the interdiffusion of polyelectrolytes and substantially increases the mechanical strength of the macroporous films, more than three orders of magnitude, making the pore walls highly tolerant of the capillary pressure. The stability of macroporous polyelectrolyte films to ethanol enables the repeated wicking from the ethanol solution of drugs, leading to a higher loading beyond previous studies. Such a high loading is favorable for the long-term release of drugs from the surfaces of modified substrates and maintaining a local drug concentration above the minimum effective concentration.
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