Among patients with unstable angina or myocardial infarction without ST-segment elevation, prasugrel did not significantly reduce the frequency of the primary end point, as compared with clopidogrel, and similar risks of bleeding were observed. (Funded by Eli Lilly and Daiichi Sankyo; TRILOGY ACS ClinicalTrials.gov number, NCT00699998.).

This paper shows the impact of COVID-19 on the global stock indices through the use of comparative analysis. Stock indices are presented by regions (Africa, Americas, Europe, Asia, and Oceania) and national stock indices are compared based on historical data. A 2:4 month ratio is used as a "window" for observing the changes in the movement of the price of indices from November-December 2019 and January-May 2020 respectively. COVID-19 infection count, recovery rate, and death rate are identi ed in each country from the rst case recorded up to May 20, 2020. Based on analysis it appeared that there is no su cient evidence to conclude that the changes in the value of indices is affected by the COVID-19 infection count (p-value = 0.9129). In Africa, only INDZI (Zimbabwe) showed a positive change of price in percentage points (1.39%) for January to May 2020 with 51 con rmed COVID-19 cases. In Asia, only SZSE (China) showed a positive mean change of price in percentage points (0.07%) in the same period with 82,971 con rmed cases. Similarly, in Europe, only OMXC20 (Denmark) showed the same with (0.09%) with 11,182 con rmed cases. In the Americas, NYSE Arca (US), Nasdaq100 (US), and MERVAL (Argentina) showed a positive mean change in price in percentage points (0.31%, 0.20%, and 0.89%) with 1,620,902 and 9,918 con rmed cases respectively. On the other hand, in Oceania, both NZX 50 (New Zealand) and S&P/ASX20 (Australia) showed a negative mean change in prices (-0.03 &-0.15) respectively. In general Asian and European indices suffered a 0.28% decrease in the mean change in daily prices as compared during November to December 2019. African indices on average stood to be the least affected with 0.11% mean change in daily prices as compared to-0.02% from November to

Coronary artery disease (CAD) causes more than 700,000 deaths each year in China. Previous genome-wide association studies (GWAS) in populations of European ancestry identified several genetic loci for CAD, but no such study has yet been reported in the Chinese population. Here we report a three-stage GWAS in the Chinese Han population. We identified a new association between rs6903956 in a putative gene denoted as C6orf105 on chromosome 6p24.1 and CAD (P = 5.00 × 10⁻³, stage 2 validation; P = 3.00 × 10⁻³, P = 1.19 × 10⁻⁸ and P = 4.00 × 10⁻³ in three independent stage 3 replication populations; P = 4.87 × 10⁻¹², odds ratio = 1.51 in the combined population). The minor risk allele A of rs6903956 is associated with decreased C6orf105 mRNA expression. We report the first GWAS for CAD in the Chinese Han population and identify a SNP, rs6903956, in C6orf105 associated with susceptibility to CAD in this population.

No abstract

Reactive oxygen species formed within the mammalian cell can produce 8-oxo-7,8-dihydroguanine (8-oxoG) in mRNA, which can cause base mispairing during gene expression. Here we found that administration of 8-oxoGTP in MTH1-knockdown cells results in increased 8-oxoG content in mRNA. Under this condition, an amber mutation of the reporter luciferase is suppressed. Using second-generation sequencing techniques, we found that U-to-G changes at preassigned sites of the luciferase transcript increased when 8-oxoGTP was supplied. In addition, an increased level of 8-oxoG content in RNA induced the accumulation of aggregable amyloid β peptides in cells expressing amyloid precursor protein. Our findings indicate that 8-oxoG accumulation in mRNA can alter protein synthesis in mammalian cells. Further work is required to assess the significance of these findings under normal physiological conditions.