Objectives. This study is aimed at exploring the relationship of the viral load of coronavirus disease 2019 (COVID-19) with lymphocyte count, neutrophil count, and C-reactive protein (CRP) and investigating the dynamic change of patients’ viral load during the conversion from mild COVID-19 to severe COVID-19, so as to clarify the correlation between the viral load and progression of COVID-19. Methods. This paper included 38 COVID-19 patients admitted to the First Hospital of Jiaxing from January 28, 2020, to March 6, 2020, and they were clinically classified according to the Guidelines on the Novel Coronavirus-Infected Pneumonia Diagnosis and Treatment. According to the instructions of the Nucleic Acid Detection Kit for the 2019 novel coronavirus (SARS-CoV-2), respiratory tract specimens (throat swabs) were collected from patients for nucleic acid testing. Patients’ lymphocyte count and neutrophil count were determined by blood routine examination, and CRP was measured by biochemical test. Results. The results of our study suggested that the cycle threshold (Ct) value of Nucleocapsid protein (N) gene examined by nucleic acid test was markedly positively correlated with lymphocyte count ( p = 0.0445 , R 2 = 0.1203 ), but negatively correlated with neutrophil count ( p = 0.0446 , R 2 = 0.1167 ) and CRP ( p = 0.0393 , R 2 = 0.1261 ), which indicated that patients with a higher viral load tended to have lower lymphocyte count but higher neutrophil count and CRP. Additionally, we detected the dynamic change of Ct value in patients who developed into a severe case, finding that viral load of 3 patients increased before disease progression, whereas this phenomenon was not found in 2 patients with underlying diseases. Conclusion. The results of this study demonstrated that viral load of SARS-CoV-2 is significantly negatively correlated with lymphocyte count, but markedly positively correlated with neutrophil count and CRP. The rise of viral load is very likely to be the key factor leading to the overloading of the body’s immune response and resulting in the disease progression into severe disease.

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Effectively motivating social distancing—keeping a physical distance from others —has become a global public health priority during the COVID-19 pandemic. This cross-country preregistered experiment (n=25,718 in 89 countries) tested hypotheses derived from self-determination theory concerning generalizable positive and negative outcomes of different motivational messages encouraging social distancing. Participants were randomly assigned to three conditions: an autonomy-supportive message promoting reflective choices, a controlling message that was restrictive and shaming, or no message. Results partially supported experimental hypotheses: the controlling message increased defiance relative to the autonomy-supportive message and increased controlled motivation (which itself correlated with more defiance and less long-term behavioural intentions to engage in social distancing) relative to no message, but messages did not influence behavioural intentions. Despite small experimental effects on defiance and motivation (rs= .07 and .10), this work highlights the potential harm of controlling public health messages and potential benefits of autonomy-supportive ones.