Students' fatigue is a serious problem which affects the quality of teaching and the physical and mental health of students and must be paid attention to by the whole society and medical workers. This study was a prospective cohort study of fatigue related problems among computer science majors at a university. With reference to "Fatigue scale-14", combining with the learning characteristics of students in Chinese education system and applying the statistical principle, the "Fatigue Scale-18" was developed. In spring, summer, autumn and winter, 319 and 1276 college students were monitored for fatigue incidence, fatigue degree and gender differences. The incidence of fatigue was 64.97%, 70.73% in boys and 61.46% in girls. Psychological fatigue accounted for 79.33% and physiological fatigue accounted for 20.67%. The main causes of fatigue were analyzed. The influence of fatigue on teaching effect is empirically studied, and the influence of fatigue on learning of students with different learning foundations is studied. Effects of fatigue incidence in different climates on learning outcomes. Based on the above research, the quantitative relationship between academic performance and fatigue degree and gender was listed as follows: academic performance =90.208—2.906× fatigue grade—4.380× gender (boy 1, girl 2). Corresponding preventive measures are put forward in view of the causes of fatigue among college students, and it is suggested that the incidence of fatigue should be controlled below 30%; it is proposed that college education should pay attention to student fatigue, monitor students' fatigue status regularly or irregularly, and take corresponding preventive measures for the causes of fatigue. Reduce the impact of student fatigue on learning and health. It provides theoretical and empirical basis for preventing students' fatigue, improving teaching quality and ensuring students' health.
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