Three 8-hydroxyquinolato (q) boron compounds B(C 2 H 5 ) 2 q (1), BPh 2 q (2), and B(2-naph) 2 q (3) have been synthesized by the reaction of 8-hydroxyquinoline with an appropriate BR 3 compound. Compounds 1-3 have a tetrahedral geometry as demonstrated by the structure of 1 determined by a single-crystal X-ray diffraction analysis. Compounds 1-3 emit a greenblue color at λ max ) 495-500 nm when irradiated by UV light. The electroluminescent (EL) properties of 2 and 3 were examined by fabricating EL devices using 2 and 3 as the lightemitting layer, respectively. The devices of 2 produce a yellow-green light with broad emission spectra, attributed to the formation of an exciplex of 2 with the N,N′-di-1-naphthyl-N,N′diphenylbenzidine (NPB) in the hole transport layer while the intrinsic EL emission of compound 3 was observed. Both 2 and 3 were found to be good electron transport materials in EL devices.

Hydrodeoxygenation (HDO) of lignin-derived phenolic compounds is one of the most promising strategies for the practical conversion of biomass materials to chemicals and fuels. Several consecutive and parallel reactions such...

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To contribute molecular diversity for novel fungicide development, a series of novel thiazole carboxamides were rationally designed, synthesized, and characterized with the succinate dehydrogenase (SDH) as target. Bioassay indicated that compound 6g showed the similar excellent SDH inhibition as that of Thifluzamide with IC 50 of 0.56 mg/L and 0.55 mg/L, respectively. Some derivatives displayed improved in vitro fungicidal activities against Rhizoctonia cerealis and Sclerotinia sclerotiorum with EC 50 of 1.2−16.4 mg/L and 0.5−1.9 mg/L. Surprisingly, 6g showed promising in vitro fungicidal activities against R. cerealis and S. sclerotiorum with EC 50 of 6.2 and 0.6 mg/L, respectively, which was superior to Thifluzamide with the EC 50 of 22.1 and 4.4 mg/L, respectively. Additionally, compounds 6c and 6g displayed excellent in vivo fungicidal activities against S. sclerotiorum on Brassica napus L. leaves with protective activity of 75.4% and 67.3% at 2.0 mg/L, respectively, while Thifluzamide without activity at 5.0 mg/L. Transcriptomic analysis of S. sclerotiorum treated with 6g by RNA sequencing indicated the down-regulation of succinate dehydrogenase gene SDHA and SDHB, and the inhibition of the TCA-cycle.

Phage therapy is recognized as a promising alternative to antibiotics in treating pulmonary bacterial infections, however, its use has not been reported for treating secondary bacterial infections during virus pandemics such as coronavirus disease 2019 (COVID-19). We enrolled 4 patients hospitalized with critical COVID-19 and pulmonary carbapenem-resistant Acinetobacter baumannii (CRAB) infections to compassionate phage therapy (at 2 successive doses of 10 9 plaque forming unit phages). All patients in our COVID-19-specific intensive care unit (ICU) with CRAB positive in bronchoalveolar lavage fluid or sputum samples were eligible for study inclusion if antibiotic treatment failed to eradicate their CRAB infections. While phage susceptibility testing revealed an identical profile of CRAB strains from these patients, treatment with a pre-optimized 2-phage cocktail was associated with reduced CRAB burdens. Our results suggest the potential of phages on rapid responses to secondary CRAB outbreak in COVID-19 patients.

Bright blue light with a maximum at 450 nm is emitted by both structural isomers of the novel, stable B (O)(7-azain) Ph (7-azain=7-azaindole anion) on irradiation with UV light. The isomer shown in the picture has approximate C symmetry (the other isomer approximate C symmetry) and electroluminesces when used as the emitting layer in an electroluminescent device.

Four novel blue/green luminescent compounds, Zn(2-py-in)2(THF) (1), BPh2(2-py-in) (2), Be(2-py-in)2 (3), and BPh2(2-py-aza) (4), where 2-py-in = 2-(2-pyridyl)indole and 2-py-aza = 2-(2-pyridyl)-7-azaindole, have been synthesized and fully characterized. The 2-py-in ligand and 2-py-aza ligand in the new compounds are chelated to the central atom. Compounds 2−4 are air stable and readily sublimable, with a melting point above 250 °C. In the solid state, compounds 1−4 have an emission maximum at λ 488, 516, 490, and 476 nm, respectively. The structures of compounds 2 and 4 are similar. The blue shift of emission energy displayed by compound 4, in comparison to that of 2, is attributed to the presence of an extra nitrogen atom in the 2-py-aza ligand as confirmed by ab initio calculations on compounds 2 and 4. Electroluminescent devices of compounds 3 and 4 were fabricated by using N,N ‘-di-1-naphthyl-N,N ‘-diphenylbenzidine (NPB) as the hole transporting layer, Alq3 (q = 8-hydroxyquinolato) as the electron transporting layer, and compound 3 or 4 as the light emitting layer. At 20 mA/cm2 the EL device of 3 has an external efficiency of 1.06 cd/A while the EL device of 4 has an external efficiency of 2.34 cd/A, demonstrating that compounds 3 and 4 are efficient and promising emitters in electroluminescent devices.