Age-related macular degeneration (AMD) is a retinal disorder affecting the elderly, and society’s aging population means that the disease is becoming increasingly prevalent. The vision in patients with early AMD is usually unaffected or nearly normal but central vision may be weakened or even lost if timely treatment is not performed. Therefore, early diagnosis is particularly important to prevent the further exacerbation of AMD. This paper proposed a novel automatic detection method of AMD from optical coherence tomography (OCT) images based on deep learning and a local outlier factor (LOF) algorithm. A ResNet-50 model with L2-constrained softmax loss was retrained to extract features from OCT images and the LOF algorithm was used as the classifier. The proposed method was trained on the UCSD dataset and tested on both the UCSD dataset and Duke dataset, with an accuracy of 99.87% and 97.56%, respectively. Even though the model was only trained on the UCSD dataset, it obtained good detection accuracy when tested on another dataset. Comparison with other methods also indicates the efficiency of the proposed method in detecting AMD.

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Lesion segmentation is a critical task in skin cancer analysis and detection. When developing deep learning-based segmentation methods, we need a large number of human-annotated labels to serve as ground truth for model-supervised learning. Due to the complexity of dermatological images and the subjective differences of different dermatologists in decision-making, the labels in the segmentation target boundary region are prone to produce uncertain labels or error labels. These labels may lead to unsatisfactory performance of dermoscopy segmentation. In addition, the model trained by the errored one-hot label may be overconfident, which can lead to arbitrary prediction and model overfitting. In this paper, a superpixel-oriented label distribution learning method is proposed. The superpixels formed by the simple linear iterative cluster (SLIC) algorithm combine one-hot labels constraint and define a distance function to convert it into a soft probability distribution. Referring to the model structure of knowledge distillation, after Superpixel-oriented label distribution learning, we get soft labels with structural prior information. Then the soft labels are transferred as new knowledge to the lesion segmentation network for training. Ours method on ISIC 2018 datasets achieves an Dice coefficient reaching 84%, sensitivity 79.6%, precision 80.4%, improved by 19.3%, 8.6% and 2.5% respectively in comparison with the results of U-Net. We also evaluate our method on the tasks of skin lesion segmentation via several general neural network architectures. The experiments show that ours method improves the performance of network image segmentation and can be easily integrated into most existing deep learning architectures.