Sentinel lymph node (SLN) refers to the initial site of the lymphatic
drainage from a primary tumor area. Accordingly, sentinel lymph node
mapping (SLNM) has been brought up and widely applied to cancer therapy
for its illuminating role in clinical lymph node resection. Furthermore,
sufficient information to guide surgical pathological staging and
adjuvant treatment in endometrial cancer can be rendered by SLNM, hence
minimizing surgery injury and reducing the incidence of complications.
This review aims to systematically summarize the advances and
application prospects of SLNM in endometrial cancer, with an expectation
of furnishing reference for the clinical application.
Exosomes are nano-sized vesicles derived from the endosomal system and
involved in multitudinous biological and pathological processes.
Emerging evidence has demonstrated that exosomes are closely related to
the tumorigenesis and progression of ovarian cancer. Ovarian
cancer-related exosomes have cell-specific constituents that could be
leveraged for diagnosis. Additionally, exosomes are promising to treat
ovarian cancer through functioning as delivery systems or participating
in immunotherapy or serving as direct targets. In this review, we
discussed the association of exosomes in ovarian cancer progression and
look forward to the clinical significance of exosomes relevant to
diagnosis and treatment.
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