OBJECTIVEFibroblast growth factor 19 (FGF19), a hormone secreted from the small intestine, has recently been shown to stimulate glycogen synthesis and inhibit gluconeogenesis through insulin-independent pathways. This study investigated the change of FGF19 in prediabetes and newly diagnosed type 2 diabetes mellitus (T2DM) and explored the association of serum FGF19 levels with parameters of glucose metabolism in Chinese subjects.RESEARCH DESIGN AND METHODSFasting serum FGF19 levels were determined by ELISA in 81 normal glucose tolerance (NGT), 91 impaired fasting glucose (IFG), 93 impaired glucose tolerance (IGT), and 104 newly diagnosed T2DM subjects, and their association with parameters of glucose metabolism was studied. An ordinal logistic regression analysis was performed in subjects with NGT, IFG, and T2DM. Serum FGF19 levels at 2 h after a 75-g oral glucose tolerance test in the different glucose tolerance categories were studied in a subgroup.RESULTSFasting serum FGF19 levels in subjects with IFG (210 pg/mL [142–327]) (median [interquartile range]) and T2DM (196 pg/mL [137–280]) were significantly lower than those in NGT subjects (289 pg/mL [224–393]) (both P < 0.001). However, no significant difference in fasting FGF19 levels was observed between IGT (246 pg/mL [138–379]) and NGT subjects. Fasting serum FGF19 levels were negatively associated with fasting plasma glucose and independently associated with the deterioration of glucometabolic status from NGT to IFG and T2DM.CONCLUSIONSFasting serum FGF19 levels were decreased in Chinese subjects with IFG and inversely associated with fasting glucose levels.
Objectives
To investigate the associations of thyroid-stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) with body mass index (BMI) and the effect of age and gender on these relationships in a large Chinese population.
Methods
A total of 97,997 individuals from a health examination center were selected. The medians (25th and 75th) of TSH, FT3 and FT4 were used to explore the trends based on gender, 10-year age groups and BMI. The relationships of TSH, FT3 and FT4 with BMI were assessed by generalized additive models (GAM) along with adjusting the effect of age and gender.
Results
After applying our exclusion criteria, 77,991 euthyroid participants (45,428 males and 32,563 females) were analyzed. The medians of TSH level based on BMI groups were significantly higher in female participants than those in males in all age groups (P < 0.05), and the median FT3 level was lower in female subjects; however, there was no significant difference between male and female subjects in median FT4 level. The GAM analysis showed the non-linear positive association of TSH and FT3 with BMI, and these relationships were markedly influenced by age and gender. However, FT4 had a negative relationship with BMI, with neglectable effect of age and gender.
Conclusions
TSH, FT3 and BMI have a non-linear and positive quadratic relationship after age and gender adjustment. FT4, however, has a negative non-linear relationship with BMI with neglectable influence of age and gender.
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