This study presents
an efficient strategy for constructing 1,2-difunctionalized
quinoline derivatives via the multicomponent cascade coupling of N-heteroaromatics with alkyl halides and different terminal
alkynes. This reaction was achieved through sequential functionalization
at the one- and two-positions of quinolines, which displayed a broad
substrate scope, environmental friendliness, excellent functional
group tolerance, high atom efficiency, and chemoselectivity. The multicomponent
coupling involved the abnormal construction of new C–N, CC,
and CO bonds in one pot. The applicability of this method
was further demonstrated by the late-stage functionalization of complex
drug molecules under the established conditions.
A one-pot protocol for constructing 1,4difunctionalized quinoline/pyridine derivatives via the reaction of N-heteroaromatics, alkyl halides, and active methylene/methyl compounds was developed. The transformation involves dearomative functionalization of an in situ-activated N-heteroaromatic to construct new CÀ N and C=C bonds. This reaction has a broad substrate scope and functional group tolerance.
This paper utilizes a hybrid Debye model to accurately simulate the relaxation response process of the oil-paper insulation of a transformer to explore the application of frequency domain dielectric spectroscopy (FDS) in nondestructive diagnosis of the aging condition of oil-paper insulation. Via FDS test data, the model parameters can be identified, and the influence laws of FDS can be obtained through the variation of model parameters. To explore the effects of insulating paper moisture content, insulating paper layers, and test temperature on FDS characteristics, an FDS experimental platform is established. The results show that the hybrid Debye model can effectively reflect the relaxation response process of oil-paper insulation under different conditions, as well as that a physical relationship between the model parameters and oil-paper dielectric polarization exists. In addition, the parameters of the hybrid Debye model can be used as the characteristic quantities for the non-destructive evaluation of the oil-paper insulation state, providing new ideas for the non-destructive evaluation of the oil-paper insulation state.
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