SiO based materials have attracted attention as a promising anode for practical application in lithium−ion batteries (LIBs) with high energy density. However, severe volume variation and poor conductivity hinder the...
The β-carboline alkaloids possess a diverse range of important biochemical effects and pharmacological properties. Sixteen 3-methyl-β-carboline derivatives were synthesized from indole formaldehyde and nitroethane via the Henry reaction, LAH/THF reduction, the Pictet-Spengler reaction and Pd/C/xylene oxidation, including four 1-substituted and twelve 9-substituted 3-methyl-β-carboline derivatives. The structures of all the derivatives were confirmed by 1 H NMR, 13 C NMR and ESI-MS. Most of these 3-methyl-β-carboline derivatives showed some antibacterial activity.
In order to develop new biorational pesticides and clarify the potential structural factors needed for the biological activity of celangulin-V analogues, thirty novel nitrogenous derivatives were designed and synthesized. The single crystal structure of celangulin-V is reported for the first time and provides a more accurate structure than that previously reported. The structures of all the new derivatives were confirmed by either NMR or ESI-MS n analysis. Insecticidal activities of these compounds were tested against the third-instar larvae of Mythimna separata. One derivative (1-6) showed higher insecticidal activity than celangulin-V, with a KD 50 of 231.2 μg.g-1 , while two compounds (2-13 and 2-14) exhibited lower insecticidal activities; the others revealed no activity at a concentration of 20 mg mL −1. The results support the view that celangulin-V has the potential to be a lead structure of semi-synthetic green insecticides.
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