Abstract:The polycondensation of guanidine hydrochloride and diamine leads to various types of oligoguanidines, including linear and branched/cyclic types, which constitutes the mixture of oligoguanidines exhibiting efficient biocidal activities. In the present work, a series of polyhexamethylene guanidine hydrochloride (PHMG) were prepared by varying the mole ratio of hexamethylenediamine to guanidine hydrochloride and the reaction conditions, and their antibacterial activities were investigated. The contents of linear and branched/cyclic types in the mixture varied with different reaction conditions, and more branched/cyclic types led to more efficient antibacterial activity. Other oligoguanidines PDMG and PMXMG were synthesized using guanidine hydrochloride and decamethylenediamine and 1,3-benzenedimethanamine, respectively. Their chemical structures were similar to PHMG's while the antibacterial activities were slightly different from PHMG's. Further when the polycondensation were conducted between guanidine hydrochloride and multi-amine, such as diethylenetriamine or trithylenetetramine, the chemical structures of products were completely different from the above oligoguanidines. A new five-membered ring structure was observed, and the fivemembered ring structure further decreased the antibacterial activities.
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