BackgroundThe co-existence of coronary heart disease (CHD) and lung cancer is increasing in an increasingly aging population. The aim of this study was to evaluate patient outcome from combined off-pump coronary artery bypass graft (CABG) surgery and lung resection in patients more than 50 years-of-age.Material/MethodsA retrospective clinical study of 23 patients with a mean age of 70.2±8.4 years (range, 51–86 years) included 18 men and five women with CHD and lung cancer who underwent a single operation with combined off-pump CABG surgery and lung resection, for non-small cell lung cancer (NSCLC) (n=22) and small cell lung cancer (n=1). Surgical approaches included: median sternotomy in six patients; left lateral thoracotomy in nine patients; a median sternotomy in three patients; median sternotomy combined with thoracoscopic lobectomy in five patients.ResultsIn the retrospective study of 23 patients, there were no deaths and no new cases of myocardial infarction (MI) in the immediate perioperative period. During the follow-up period, six patients died from lung cancer metastasis or recurrence; one patient died of acute renal failure; and one patient died from the effects of chemotherapy. The remaining 15 patients underwent postoperative follow-up for between 3–79 months with no deaths and no new cases of MI.ConclusionsFor patients who are more than 50 years-of-age and who have CHD and lung cancer, a single combined operation that includes off-pump CABG and lung resection can be safe and effective.
Metal-organic frameworks (MOFs) have great potential for the capture of volatile iodine. The effect of a precise regulation of active sites in JLNU-4 (MOFs) on capture of iodine was investigated by Monte Carlo (MC) method and molecular dynamics (MD), and it was found that the larger the Zn/Cd atomic ratio, the better the iodine capture. Interestingly, compared with the meta-position regulation of Zn/Cd, the ortho-positions regulation increased the free volume of the crystal and enhanced the interaction between Cd and I, thus improving the capture capacity of iodine. The first-principles study revealed the charge transfer of each atom in the MOFs crystal with I2 during iodine capture and the secondary bonds with weak covalent interactions were all formed after I2 adsorption onto MOFs. These findings provide a reference for the capture of radioactive iodine and a theoretical basis for the strategies for precise regulation of MOFs in the future.
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