A mild and efficient DBN-mediated addition reaction of α-(trifluoromethyl)styrenes with diazoles, triazoles, tetrazoles, and primary, secondary, and secondary cyclic amines was developed. This practical protocol provided a robust method for the synthesis of various βtrifluoromethyl nitrogen-containing heterocycles and β-trifluoromethyl amines.
An efficient solvent-free synthesis of β-CF3-substituted phosphonates and phosphine oxides via hydrophosphonylation and hydrophosphinylation of α-CF3 styrenes with H-phosphonates and H-phosphine oxides was developed.
Four unprecedented base-catalyzed/mediated nucleophilic additions of TMSCN to α-(trifluoromethyl)styrenes and 2-trifluoromethyl enynes were developed. The reaction proceeded smoothly at room temperature under mild and transition-metalfree conditions without affecting the trifluoromethyl group and afforded the corresponding CF 3 -containing alkyl, alkynyl, and butadienyl nitriles in moderate to excellent yields in a highly regioselective manner, respectively.
A mild and practical Fe-catalyzed hydroxytrifluoromethylation of α-(trifluoromethyl)styrenes with CF3SO2Na in the presence of K2S2O8 and air was developed. The reaction proceeded efficiently at room temperature without β-fluoride elimination and...
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