Background:
The treatment of post-stroke depression (PSD) with anti-depressant drugs is partly practical. Transcranial alternating current stimulation (tACS) offers the potential for a novel treatment modality for adult patients with PSD. In this study, we will assess the efficacy and safety of tACS for treating PSD and explore its effect on gamma and beta-oscillations involving in emotional regulation.
Methods:
The prospective study is an 8-week, double-blind, randomized, placebo-controlled trial. Seventy eligible participants with mild to moderate PSD aged between 18 years and 70 years will be recruited and randomly assigned to either active tACS intervention group or sham group. Daily 40-minute, 77.5-Hz, 15-mA sessions of active or sham tACS targeting the forehead and both mastoid areas on weekdays for 4 consecutive weeks (week 4), and an additional 4-week observational period (week 8) will be followed up. The primary outcome is the proportion of participants having an improvement at week 8 according to the Hamilton Depression Rating Scale 17-Item (HAMD-17) score, including the proportion of participants having a decrease of ≥ 50% in HAMD-17 score or clinical recovery (HAMD-17 score ≤ 7). Secondary outcomes include neurological function, independence level, activities of daily living, disease severity, anxiety, and cognitive function. The exploratory outcomes are gamma and beta-oscillations assessed at baseline, week 4, and week 8. Data will be analyzed by logistical regression analyses and mixed-effects models.
Discussion:
The study will be the first randomized controlled trial to evaluate the efficacy and safety of tACS at a 77.5-Hz frequency and 15-mA current in reducing depressive severity in patients with PSD. The results of the study will present a base for future studies on the tACS in PSD and its possible mechanism.
Trial registration number: NCT03903068, pre-results.
According to the characteristics of adult higher education, this paper expounds the necessity of cultivating the information quality of adult students. This paper gives full play to the functions of university library, and combined with practical measures, puts forward some effective ways for university library to implement adult education service.
Finance is becoming more important in the national economy. Maintaining financial stability is critical not only for the financial industry’s prosperity and development, but also for a country’s political, economic, and social development. This paper will look at the mechanisms that cause systemic risk to develop and evolve, as well as how to measure systemic financial risk in multiple dimensions. To begin, create a system for evaluating financial risk in a systematic manner. Second, using the AHP and CRITIC methods to determine various indicators and market weights, create a systemic financial risk evaluation model based on the system dynamics model, and calculate the system from 2010 to 2019 comprehensive financial risk index. Finally, simulation research is conducted using the system dynamics model of systemic financial risk, and the simulation results are analyzed. The findings show that China’s financial risk has been gradually increasing since 2016, with relatively small fluctuations in risk state.
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