Polyetheretherketone
(PEEK) is becoming an attractive surgical
implant material in the biomedical field. However, its hydrophobicity
and biological inertia have seriously hindered its development in
the field of biomaterials and application in clinic. In this work,
a mixed modification approach of the surface structure and chemical
state was proposed to improve hydrophilicity and bioactivity of PEEK
and meanwhile endowed it with antimicrobial properties. First, the
effect of mixed acids of nitric acid and concentrated sulfuric acid
with different volume ratios on the surface morphology of PEEK was
quantitatively investigated, so as to obtain an optimal mixed acid
of nitric acid and concentrated sulfuric acid with a volume ratio
that could create a multilevel porous structure. Based on this, chemical
grafting of ethylenediamine was conducted to achieve amination on
the surface of the PEEK. The results showed that such double modification
of the surface structure and chemical state could endow PEEK not only
with antimicrobial activity but also with good hydrophilicity, cell
compatibility, and bioactivity, which were beneficial to improve the
bone integration ability of PEEK greatly.
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