Objective: To investigate the changes in serum levels of ghrelin, tumor necrosis factor-α and interleukin-6 in Children with Congenital Heart Disease (CHD) at pre and post percutaneous management of the lesions. Material & Methods: We measured the serum levels of ghrelin, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) by enzyme linked immunosorbent assays (ELISA) in 67 patients with CHD and in 20 control subjects; and compared these markers of inflammatory reaction between groups of pre-closure (37 patients) and at the end of 5 minutes (37 patients), 1 month (22 patients) and 3 month (8 patients) post percutaneous management of the lesions. Results: Our results showed that the patients with CHD had significantly higher serum level of Ghrelin, TNF-α and IL-6 in comparison of the controls but gradually return towards the baseline levels at the end of 3 months post percutaneous management of the lesions. Conclusion: The inflammatory reaction is activated in pre-closure and self-limited post-closure in children with CHD. Percutaneous management could improve the inflammatory process, which is safe and effective in children with CHD.
Background and Aim: Coronary artery fistulae (CAF) are rare anomalies. In this study, we have done percutaneous closure of CAF in children with three different devices; ventricle septal defect (VSD) occluder, patent ductus arterious (PDA) occluder and Cook coil.Materials and Methods: We retrospectively reviewed all patients, admitted to our heart center inpatient department between September 2004 and April 2013, that had a percutaneous closure of CAF in our center, and evaluated outcomes of patients with CAF treated with cardiac catheterization.Results: A total of fi ve patients (3 females) ranged in age from7 months to 10 years with congenital CAF underwent percutaneous closure. The fistulae had origins from right coronary artery (RCA) and from left coronary artery (LCA) in 3 cases and 2 cases respectively. One RCA drained to right atrium and rest four drained to right ventricle. All 5 cases had a co ntinuous murmur. During closure, 2 fistulae closed with VSD occluder, 2 with PDA occluder & 1 with Cook coil. Percutaneous closure was successfully achieved in all the 5 patients. Follow-up studies showed that there was complete abolition without recanalization. No deaths occurred.Conclusion: Percutaneous closure of congenital CAF is very safe and effective in children with less complication and shorter hospital stay.DOI: http://dx.doi.org/10.3126/ajms.v6i4.11786 Asian Journal of Medical Sciences Vol.6(4) 2015 45-50
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.