SummaryS100A8, the light subunit of calprotectin, has been known to be associated with periodontal inflammation. The present study looked to detect whether three polymorphisms in the upstream region of the S100A8 gene are correlated with periodontitis. Three hundred and twenty one subjects, including chronic periodontitis (CP) patients, aggressive periodontitis (AgP) patients and periodontally healthy controls, were recruited. The SNPs rs3795391, rs3806232 and rs3885688 were analyzed by PCR-RFLP analysis. No person carried the rs3885688 polymorphism in this cohort. For the other two polymorphisms, the combined effects of genotype/allele and gender were shown to be associated with the risk of periodontitis using multivariate logistic regression analysis. The G + genotype/G allele may be considered to exert a significant protective effect in males against AgP (Genotype: rs3795391: P = 0.032, rs3806232: P = 0.017; Allele: rs3795391: P = 0.024, rs3806232: P = 0.013). Although the combined effects of genotype and gender on CP susceptibility were not observed for these two polymorphisms, there does seem to be increased risk of CP in males with allele A compared to females with allele A (rs3795391: P = 0.008; rs3806232: P = 0.009). Hence we found an important association between polymorphisms in the S100A8 gene and periodontitis in a Chinese population.
Carbonate cemented zones are normally adjacent to the top overpressured surface in the central Junggar Basin, NW China. Stable carbon and oxygen isotopic compositions and petrological investigations of carbonate cements in the carbonate cemented zones indicate that: (1) carbonate cements are composed dominantly of ferrocalcite, ferroan dolomite, and ankerite; (2) carbonate cements are formed under a high temperature circumstance in the subsurface, and organic fluid migration has an important effect on the formation of them; and (3) carbon and oxygen ions in the carbonate cements migrate from the underlying overpressured system. This suggests that the occurrence of carbonate cemented zones in this region results from multiple phases of organic fluid expulsion out of the overpressure compartment through geological time. This study provides a plausible mechanism of the formation of carbonate cemented zones adjacent to the top overpressured surface in the clastic sedimentary basins, and has an important implication for understanding the internal correlation between the formation of carbonate cemented zones adjacent to top overpressured surface and geofluids expulsion out of overpressured system. carbonate cemented zones, formation mechanism, stable carbon and oxygen isotopic, top overpressured surface, central Junggar Basin, coal-bearing strata Citation:Yang Z, Zou C N, He S, et al. Formation mechanism of carbonate cemented zones adjacent to the top overpressured surface in the central JunggarAs one of the most familiar diagenetic authigenous minerals in clastic reservoirs, carbonate cements, have variable mineralogy, texture and chemical compositions, and can be formed under various geochemical conditions [1, 2]. Previous work on carbonate cements focuses mainly on their influences on reservoir quality, tracing the sources and migration-pathways of geofluids and the sealing effects of geofluids [2][3][4][5][6][7]. Most studies hold that carbonate cementation is a destructive diagenetic process, because reservoir quality becomes much worse than before due to the cements' filling into the pores and thus decreasing the porosity and permeability of the reservoir, and improving heterogeneity of the reservoir by dividing thick sandstone bodies into thinner units [4,[8][9][10][11][12][13][14]. Carbonate cements formed in different phases record variations in fluid compositions during the course of diagenesis, which helps decipher the processes of fluid-rock interaction and fluid composition evolution at geological time scale [2,5,[15][16][17][18][19][20][21][22][23][24]. Particularly,
Embedding thread lift rhytidectomy, also known as “thread lifting” in China, with the natures of simple operation, less trauma and quick recovery, is progressively used in clinical practice as a new technology of face lifting. Herewith, a brief introduction of the previous advances of thread lifting techniques and materials in the facial beauty industry, combined with the discussion on various types of sutures, common complications, and the site of actions were provided. The main limitations of present thread lifting material include: (1) the use of non-absorbable sutures is liable to cause allergies and a series of complications; (2) the absorbable sutures are easily degradation, and people need to reshape in a relatively short period. Therefore, the high biocompatible spider silk was proposed as a novel material of thread lifting suture and related devices, the advantages and preliminary achievements on spider silk were also addressed. Graphic Abstract
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