Objective: Synchronic colorectal peritoneal carcinomatosis (SCRPC) was recognized as a predictor of poor prognosis. The aim of this study was to investigate the role of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) on the survival outcome, which might help determine the treatment management of SCRPC patients. Methods: A total of 103 SCRPC patients following cytoreduction surgery (CRS) and systematic chemotherapy (CT) between 1997 and 2013 in the First Affiliated Hospital of Sun Yat-sen University were retrospectively analyzed. The comparison of the clinicopathological variables and systematic inflammatory biomarkers, including NLR, PLR and SII, was performed by Chi-test and Cox regression analysis. According to the results of multivariate analysis, a prognostic nomogram was generated, and its prediction ability was measured by the concordance index (C-index). The survival curves were generated using the Kaplan-Meier method and survival comparison between groups was conducted via the log-rank test. Results: Univariate analysis revealed that elevated NLR, PLR and SII were significantly correlate with worse survival outcome. Only low SII value was recognized as an independent favorable prognostic factor for overall survival (HR=1.772, 95% CI=1.015-3.095, P=0.044), except for NLR and PLR. The nomogram could perform well in the prediction of overall survival in SCRPC patients (c-index 0.782). Moreover, SII had strong prognostic discriminatory ability to predict survival outcome for the patients receiving completeness of cytoreduction score (CCR) 0/1 or CCR2/3, rather than NLR and PLR. Conclusions: SII was a better inflammation factor to predict the outcomes of SCRPC patients receiving CRS and systematic CT. Low SII value was the most favorable factor benefiting from different level of CRS and it was useful for determining the appropriate treatment strategy for SCRPC patients.
Liquid metals (LMs) possess tremendous potential applications in flexible electronic devices, heat flow management, and smart actuators. Splitting the bulk LMs into microspheres is of great significance to fabricate free-standing and microscale LM-based functional materials and devices. However, it is difficult to disperse the bulk LMs into microspheres because of their large surface tension and high density. In this work, the capillary-based microfluidic chip is employed to continuously and automatically generate LM microspheres in a large scale. The capillary-based microfluidic fabrication is universally applicable in ionic aqueous solution, hydrophobic solution, and the polymeric aqueous solution. The precise size control of LM microspheres can be easily realized by the co-flowing configuration in the microchannels. The coefficient of size variation of monodispersed LM microspheres can be controlled to as low as 0.47%. The free-standing LM microspheres can be used as functional microelectrodes within a wide temperature range from −19.8 to 20 °C and to fabricate tunable integrated circuits with different output powers. Most importantly, the LM microspheres exhibit photothermal property, which is used to make the optical sensor with linear response and to conduct the solar energy harvesting. The capillary-based microfluidic fabrication of LM microspheres provides a facile and templated methodology for processing bulk LMs into microscale units. The LM microspheres with excellent electrical conductivity and photothermal property hold great promise for the development of miniature soft electronics, light-driven actuators, and energy conversion medium.
The application of Shenfu injection exhibited a positive and effective effect on removing the inflammation media during the treatment of elderly severe pneumonia.
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