Background: To explore the mechanism of action of Tripterygium wilfordii Hook (TWH) in the treatment of Crohn's disease (CD) by network pharmacology. Methods: Traditional Chinese Medicine Systems Pharmacology database and analysis platform (TCMSP) was used to obtain the active constituents and targets of TWH. "Crohn's disease" was used as a search term to search for related targets of CD from GeneCards database and OMIM database, thereby obtaining the targets of TWH against CD. The Cytoscape 3.7.1 software was used to construct a Chinese medicine compound-target network and STRING database to construct a protein-protein interaction network (PPI). The DAVID 6.8 online tool was used to perform gene ontology (GO) and kyoto encyclopedia of genes and genome (KEGG) pathway enrichment analysis of overlapping targets. Results: The database results showed that there were 30 active ingredients (14 key active ingredients) in TWH and 36 targets were screened out for CD treatment. Network analysis indicated that main targets of main active components of TWH were target genes such as VEGFA, MAPK8 and CASP3, which are involved in the regulation of cancer pathway, TNF signal pathway, hepatitis B pathway, apoptosis pathway, NF-kappa B signal pathway and so forth. Conclusions: TWH can play a multi-target and multi-channel synergistic treatment of CD by anti-angiogenesis, antiapoptosis, anti-inflammation and immune regulation.
Lowering the amount of excess air is believed to increase the density of the air-fuel mixture and help improve the combustion rate for compression ignition engines. This paper proposes an approach of adding a throttle body at the intake pipe to control the excess air ratio with reduction of air supply to achieve a better balance between the power, emissions and fuel efficiency at medium and low load of a natural gas dual-fuel diesel engine converted from a conventional diesel engine. Various experiments in both pure diesel and dual-fuel mode under intermediate engine speed are performed with the proposed critical method of excess air ratio control. The experimental results reveal that better excess air ratio is very beneficial for the power output and brake specific energy consumption in dual-fuel combustion under medium and low load conditions. Moreover, the substitution rate can reach as high as 40% under low load conditions with throttle control.
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