No abstract

No abstract

Hydrogen atoms absorbed by metals in hydrogen-containing environments can lead to the premature fracture of the metal components used in load-bearing conditions. Since metals used in practice are mostly polycrystalline, grain boundaries (GBs) can play an important role in hydrogen embrittlement of metals. Here we show that the reaction of GBs with lattice dislocations is a key component in hydrogen embrittlement mechanism for polycrystalline metals. We use atomistic modeling methods to investigate the mechanical response of GBs in alpha-iron with various hydrogen concentrations.Analysis indicates that dislocations impingement and emission on the GB can provoke it to locally transform into an activated state with a more disordered atomistic structure, and introduce a local stress concentration. The activation of the GB segregated with hydrogen atoms can greatly facilitate decohesion of the GB. We propose a hydrogen embrittlement model that can give better explanation of many experimental observations.

The repair of large bone defects poses a grand challenge in tissue engineering. Thus, developing biocompatible scaffolds with mechanical and structural similarity to human cancellous bone is in great demand. Herein, we fabricated a three-dimensional (3D) porous iron (Fe) scaffold with interconnected pores via a template-assisted electrodeposition method. The porous Fe scaffold with a skeleton diameter of 143 μm had the porosity >90%, an average pore size of 345 μm, and a yield strength of 3.5 MPa. Such structure and mechanical strength were close to those of cancellous bone. In order to enhance the biocompatibility of the scaffold, strontium incorporated octacalcium phosphate (Sr-OCP) was coated on the skeletons of the porous Fe scaffold. The coated Sr-OCP was in the form of nanowhiskers with a mean diameter of 300 nm and length of 30 μm. Such Sr-OCP coating could effectively reduce the release rate of the Fe ions to a level which was safe for the human body. Both in vitro cytotoxicity tests by extraction method and direct contact assay confirmed that the Sr-OCP coating could promote the cell adhesion and substantially enhance the biocompatibility of the porous Fe scaffolds. Thus, the cancellous-bone-like porous structure with compatible mechanical properties and excellent biocompatibility enables the present Sr-OCP coated porous Fe scaffold to be a promising candidate for bone repair and regeneration.

No abstract