ABSTRACT. Growth hormone (GH) plays an important role in promoting growth, protein and muscle accretion, and fat catabolism, suggesting that GH is a potential candidate gene affecting growth traits in vertebrates. In this paper, polymorphisms in GH were investigated in 632 Chinese Tibetan sheep, by using DNA sequencing. Three single nucleotide polymorphisms were identified, including two mutations (g.616G>A and g.624G>A) in intron 2 and one synonymous mutation (g.498G>C) in exon 2. Association analyses showed that both g.498G>C and g.616G>A were significantly associated with several growth traits (at P < 0.01 or P < 0.05) in three investigated breeds. Our results demonstrate that GH variation may be used as a molecular marker for growth traits in Chinese Tibetan sheep.
Little is known about the neuroendocrine impact of cocaine as it relates to pituitary growth hormone secretion. In these studies, in adult male rats, intracerebroventricular administration of cocaine caused a potent dose-related suppression of circulating growth hormone (GH) in animals sacrificed 15 min after drug administration. We conclude that in the adult male rat cocaine suppresses plasma GH levels.
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