The facile preparation of hyperbranched glycopolymers was performed without protecting group chemistry, where the methyl-6-O-methacryloyl-α-d-glucoside (6-O-MMAGlc) monomer was adopted as an AB3*-type inimer.
Heat sensitive color-developing polyurethane microcapsules containing leucocompounds were prepared by interfacial polymerization. The effects of three determinative process parameters on the particle size distributions, surface morphologies, and heat sensitive color-developing behavior of the microcapsules were investigated. As a result, the polyurethane microcapsules with a narrower distribution, rounder shape and better heat sensitive color-developing property were prepared with increasing of the protective colloid content, emulsifying rate and emulsifier content. This was related with the surface roughness of the microcapsules.
Glioma is a malignant tumor that originates in the brain and accounts for more than half of all brain tumors. The disease is associated with a high fatality rate. Satisfactory treatment cannot be achieved through conventional craniotomy. We use carboxymethyl chitosan-coated Fe3
O4 composite nanoparticles (CMCS-Fe3 O4 NPs) as a drug delivery platform, and installed transferrin (TRF) with a targeting function on the platform. The anticancer drug methotrexate (MTX) is loaded onto the composite nanomaterial to complete a new delivery
system for nano-drug targeted treatment of glioma. The composite nanoparticle is not toxic to cells in vitro, but after loading with it is loaded with MTX, it significantly inhibits proliferation of C6 cells. In vivo experiments show that CMCS-Fe3 O4NPs-TRF-MTX
has a marked therapeutic effect on glioma in mouse models. The nano complex quickly penetrates the blood-brain barrier and enters brain tissues. An aggregation effect is not obvious. MRI monitoring for up to 4.0 h shows that CMCS-Fe3 O4 NPs-TRF-MTX slowly releases drug
molecules over an extended period, thus increasing the duration of drug activity.
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