infection, insufficient angiogenesis, and excess reactive oxygen species (ROS) being the most important ones. [6,7] During the healing process of diabetic wounds, the abnormal blood glucose level may trigger an increase of bacteria, leading to wound infection and healing difficulty. Meanwhile, excessive ROS and insufficient angiogenesis may impair glucose metabolism and collagen deposition, leading to cytotoxicity and delayed healing. [8] Therefore, clearance of excess ROS, suppression of bacteria, and promotion of angiogenesis have been deemed viable approaches to facilitate the diabetic wound healing process. [9,10] On the other hand, many strategies have been developed to promote wound healing, including tissue engineering scaffolds and 3D bioprinting. [11][12][13] Various drug delivery systems based on porous materials have been explored in biomedical applications. [14][15][16][17][18] Among them, zeolitic imidazolate frameworks (ZIFs), a subclass of MOFs, are highly preferred matrices for drug delivery due to their controlled pore size, pH responsiveness, low cytotoxicity, and good biocompatibility. [19][20][21][22][23] However, the direct application of ZIF materials as drug delivery systems necessitates extensive material engineering, and it is hard to keep the moist environ ment required for wound healing. [24][25][26][27] Thus, ZIF-based composite hydrogels, benefiting from their drug release efficiency, good adhesion, and moisture retention, have attracted great research interest in the field of wound dressing. [25,[28][29][30][31] Nevertheless, ZIFs are insoluble solid particles, and the drug loading process is usually carried out in a non-homogeneous form, which may cause problems such as long adsorption time and non-sustained drug release. [32,33] Furthermore, the poor compatibility between hydrogel and ZIF particles may cause unsatisfactory mechanical properties of the composite, leading to the dressing of a failure of achieving a good wound-healing effect. Porous liquid (PL) is a class of material with permanent porosity, which has the advantages of liquid-like fluidity as well as chemical and thermal stability. [34][35][36][37][38][39][40][41] Compared to the traditional non-homogeneous drug delivery of ZIFs, [42] the porous liquid technology allows ZIF materials in a relatively homogeneous form in solvents, which makes them easier to adsorb drugs and disperse well in the medium, offering the possibility of sustained drug release and good compatibility with hydrogel.Curcumin (Cur) is a natural polyphenolic compound with antioxidant and anti-inflammatory effects. [43][44][45] Previous Porous metal-organic framework (MOF) liquids with permanent porosity, good fluidity, and fine dispersion attract broad attention in catalysis, transportation, gas storage, and chemical separations. Yet, the design and synthesis of porous MOF liquids for drug delivery remain less explored. Herein, a simple and general strategy is reported to prepare ZIF-91 porous liquid (ZIF-91-PL) via surface modification and ion exch...