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BackgroundClaudin-1 is a tight junction protein in the cell that organizes paracellular permeability and epithelial polarity and maintains apical cell-to-cell adhesion. Deregulation of claudin-1 homeostasis will play pivotal role in tumorigenesis, migration, and metastasis of colorectal cancer through a complex signaling pathway. This study investigated the association of claudin-1 expression and clinicopathological factors in colorectal adenocarcinoma. Methods This study was a cross-sectional study of 43 colorectal cancer patients. Each clinicopathological parameter data was divided into 2 categories; depth of tumor invasion (T3, T4), degree of tumor differentiation (low, high grade), tumor location (right, left), sex (man, woman) and age (<60, ≥60 y.o). Claudin-1 expression was examined by the immunohistochemistry method and evaluated by H-Score method. The H-score cut off was determined by the mean value of 148. The difference of claudin-1 expression score with tumor depth invasion and age was analyzed by Independent t-test, and then the degree of differentiation, tumor location and sex were analyzed by Mann-Whitney. All variables were analyzed by the Chi-square analysis with a significance value of P<.05.ResultsThere was a significant mean difference of claudin-1 expression between T3 and T4 tumors (P=.041; 95% CI 1.7-75.1). Tumor with low expression of claudin-1 was 2.5 times more likely to be found in tumor with invasion depth T4 rather than T3 (P=.023; 95% CI 1.5-48). In addition, tumor with low expression of claudin-1 was 0.2 times more likely to be found in the high-grade tumor (P=.001; 95% CI 0.07-0.4). Claudin-1 expression was not statistically significant in different tumor locations, sex and age group. ConclusionThere was mean difference in claudin-1 expression between T3 and T4 tumors, and between low- and high-grade tumors. The low claudin-1 expression is associated with tumor depth invasion and poorly differentiated tumors. Therefore, the use of claudin-1 as an additional prognostic factor in colorectal cancer is proposed.

Introduction: Pedunculated lipofibroma is a challenging case. It’s a slow growing mass lesion which can affect both children and adult. The diagnosis of pedunculated lipofibroma can be confused with other benign papillomas due to their characteristic appearance. Objective: To define the clinicopathological findings of pedunculated lipofibroma. Methodology: Descriptive study as case report type, which use secondary data from patient medical record. Case presentation: This paper reports a 39-year-old woman, who has a slow growing mass lesion on her left thigh for almost 3 years. The lesion start impending her daily life due to pain and the lesion get bigger which make her get trouble especially when she wants to wear her jeans. The diagnosis of pedunculated lipofibroma can be confirmed by the histopathologic findings showing isolated groups of ectopic mature adipocytes within the dermis. Generally, the tumor itself doesn’t need any specific treatment, however the location and size affect the patient performance. Conclusion: Based on clinicopathological findings, the patient diagnosed with solitary pedunculated lipofibroma located at medial femur sinistra.

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