Recombinant tissue plasminogen activator (r-tPA) is the first-line drug for the treatment of acute ischemic stroke, despite it may lead to a variety of complications in some cases. In patients with extensive stroke, infarction of the brain can cause suppression of the respiratory center in the brain leading to neurogenic pulmonary edema that potentially causes respiratory failure. Its etiology is either due to a neurogenic or non-neurogenic process. Nevertheless, the definite pathophysiology of these circumstances remains unclear. In this study, we reported four cases of post-thrombolytic ischemic stroke patients who suffer from pulmonary edema with different symptoms and onset times as well as we discuss the possible explanation behind these different outcomes.
Introduction:Jatropha curcas L is a tropical plant, besides containing antioxidants it also contains toxic compounds. This plant is believed to be anti-inflammatory, antimicrobial, antibacterial and antifertilization. It is suspected that this plant can damage tissues through oxidative stress. The liver as an organ of central metabolism and detoxification. This plant is not yet known its effect on the liver when consumed, especially on hepatocyte cells and blood flow to the central veins of the liver.Method: Mice were given a dose of jatropha seed extract (0, 5, 25, 50, 250 mg/KgBW) for 28 days. Liver homogenates were measured for MDA levels, GSH activity and their correlation using a spectrophotometry. besides measuring the diameter of the central vein of the liver. Results: MDA levels after being given Jatropha seed extract: control (0); 5; 25; 50; 250 mg/KgBW were 0.818; 1,363; 2,043; 2,720; 2,518 nmol / ml and GSH activity was 0.979; 0675; 0.621; 0.463; 0.544 μg / ml. Vein diameter 169; 140; 24; 36; 30 μm and the smallest at a dose of 25 mg / BW was 23.7 μm (ANOVA, p <0.05). The correlation of MDA and GSH levels was very strong negative (Pearson: -0918; p <0.01). Discussion:The higher dose of jatropha seed extract, significantly increases MDA levels and decreases GSH activity. The correlation between the two is very strong negative negative correlation is very significant. Jatropha seed extract with high doses causes small central vein diameters of the liver.International Journal of Human and Health Sciences Vol. 05 No. 01 January’21 Page: 41-46
Background: An acute ST-elevation myocardial infarction (STEMI) anterior occurs due to occlusion of left anterior descending artery (LAD) branch of left coronary artery. The occlusion causing transmural myocardial ischemia which in turn to myocardial infarction due to myocardial injury or necrosis. Not only Primary Percutaneous Coronary Intervention (PCI) should be performed in STEMI less than 120 minutes as the risk of the adverse events would increase if exceeding the total ischemic time, but also the procedure can be high risk in patients with multiple clinical factors or comorbidities which can increase the risk of complications.Case Report: We report a case of a 57 years old man who presented Acute STEMI Anterior, Coronary Artery Disease (CAD) 3 Vessel Diseases (VD), Hypertension Heart Disease (HHD), Chronic Kidney Disease (CKD) on Hemodialysis (HD), with COVID-19 confirmed.Results: The left coronary artery was successfully stented by PCI and Coronary Angiogram (CAG) procedures with TIMI 3 flow, minimal bleeding and others complications.
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