SpartanamicinsA and B, two antifungal antibiotics, were produced by a culture of Micromonospora spp. strain No. MSU-43097 (ATCC 53803), isolated from a potted soil containing asparagus {Asparagus officinalis L.) plants. The antibiotics were isolated from the mycelial cake using organic solvents. Micromonospora species are well known for their ability to produce biologically active compounds. Calicheamicin, approximately 1,000-fold more active than doxorubicin against murine tumors, is an unusually powerful antitumor compoundisolated from Micromonosporasubsp. echinospora calichenis1 "^. Triglycosidic antibiotics, isolated from M. inositola and M. megalomicea and other antibiotics reported from Micromonosporaspecies are chalcidin complex, everninomicins B and D4 5) and ferrioxamine B6>7).Streptomyces galilaeus produces 21 anthracycline antibiotics out of which aclacinomycins A, B, and their derivatives were studied for their antitumor activities8~14). Wereport the isolation, purification, and identification of potent antifungal compounds belonging to the anthracycline group of antibiotics. Results and DiscussionThe strain 43097 is relatively easy to grow in suspension and solid agar plates. Preliminary taxonomic studies indicated that this organism is a Micromonosporaspp. It is deep red in color on solid YMGplate at 7~8 days and orange at 3-4 days. It also grew well in all the 9 different media studied but produced spartanamicins A and B in YMGmedium only. The pH of the fermentation medium remained virtually unchanged for 12 days and the mycelium can be harvested for spartanamicins A and B between days 3-4.f US Patents 4,977,084;5,013,549;5,066,585.
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