Infection born by Coronavirus SARS-CoV-2 has swept the world within a time of a few months. It has created a devastating effect on humanity with social and economic depressions. Europe and America were the hardest hit continents. India has also lost several lives, making the country fourth most deadly worldwide. However, the infection and death rate per million and the case fatality ratio in India were substantially lower than many of the developed nations. Several factors have been proposed including the genetics. One of the important facts is that a large chunk of Indian population is asymptomatic to the SARS-CoV-2 infection. Thus, the real infection in India is much higher than the reported number of cases. Therefore, the majority of people are already immune in the country. To understand the dynamics of real infection as well as level of immunity against SARS-CoV-2, we have performed antibody testing (serosurveillance) in the urban region of fourteen Indian districts encompassing six states. In our survey, the seroprevalence frequency varied between 0.01-0.48, suggesting high variability of viral transmission among states. We also found out that the cases reported by the Government were several fold lower than the real infection. This discrepancy is majorly driven by a higher number of asymptomatic cases. Overall, we suggest that with the high level of immunity developed against SARS-CoV-2 in the majority of the districts, it is less likely to have a second wave in India.
Yagya is an ancient Hindu Vedic ritual aimed at ablution of the body and surroundings by reinforcing the natural equilibrium in various components of the body and ambient environment. Yagya is directed with selective medicinal preparation of herbs that is forfeited in the holy fire inflamed by specific woods along with the chant of distinct Vedic Hymes (mantras). Medicinal smoke significantly removes human pathogenic microbes. The vaporization and sublimation of ingredients of havan samagri in an inverted pyramid shaped yagya-kunda deliver vast amount of therapeutic and environmental benefits. The chemical transformation (into vapor or gaseous phase/ colloidal forms) of the herbal/ plant medicinal preparations in Hawan lead to release of medicinal phytochemicals; which affect many endogenous chemicals including hormonal axis. These fumes help in purifying the air and have anti-epileptic, anti-pyretic, anti-fungal, antibacterial effects amongst the numerous other benefits. Regular chanting of hyms helps in purifying the mind. Improvement has been noticed with respect to digestion, hypertension, mental agitation and sleep after chanting the Mantras.
: There is a new public health crisis threatening the world with the emergence and spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease was later named as a novel Coronavirus disease or COVID-19. It was then declared a pandemic by the World Health Organization on March 11, 2020. The virus originated in bats and was transmitted to humans through yet unknown intermediary animals in Wuhan, Hubei province, China, in December 2019. As of February 5, 2021, 103 million laboratory-confirmed cases and nearly 2.3 million deaths have been reported globally. The number of death tolls continue to rise, and a large number of countries have been forced to implement social distancing and lockdown. As per literature, Coronavirus is transmitted human to human or human to animal via airborne droplets. Coronavirus enters the human cell through membrane ACE-2 exopeptidase receptor. WHO, ECDC, and ICMR advised to avoid public places and close contact with infected persons and pet animals. To date, there is no evidence of any effective treatment for COVID-19. The main therapies being used to treat the disease are antiviral drugs, chloroquine/hydroxychloroquine, and respiratory therapy. Although several therapies have been proposed, quarantine is the only intervention that appears to be effective in decreasing the contagion rate. We conducted a literature review of publicly available information to summarize knowledge about the pathogen and the current epidemic. In the present literature review, the causative agents of the pandemic, epidemiology, pathogenesis, and diagnosis techniques are discussed. Further, currently used treatment and prevention strategies along with vaccine trials and computational tools are all described in detail.
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