PURPOSETo study the effect of systemic administration of HMG CoA reductase inhibitor Atorvastatin on Central Retinal Artery (CRA) flow dynamics, Intraocular Pressure (IOP) and Visual Field (VF) changes in Primary Open Angle Glaucoma (POAG) and Normal Tension Glaucoma (NTG) patients.
MATERIALS AND METHODSProspective randomized placebo controlled double blind parallel group study consisting of 80 eyes of 40 patients suffering from POAG and NTG was conducted. After baseline clinical evaluation and Color Doppler Imaging (CDI) of CRA subjects were randomized to receive 40mg/day of Atorvastatin (Tonact) or matching Placebo for 3 months and followed at two weeks, one month and three months. Main outcome measures were Peak Systolic Velocity (PSV), End Diastolic Velocity (EDV), Resistive Index (RI), IOP and Mean Deviation (MD) in VF.
RESULTSAtorvastatin group showed decrease in IOP (P=0.0009 in right eye and P=0.0049 in left eye) and in RI (P=0.0005 in right eye and P=0.0008 in left eye), while there was increase in RI in the placebo group (P=0.0006 in right eye and P=0.0007 in left eye) after 3 months. No significant change in MD of VF was noticed in both groups.
CONCLUSIONAtorvastatin has favorable effect in POAG and NTG patients causing decrease in IOP and resistance of CRA with increase in CRA flow dynamics.
An 11-year-old male patient presented with a gradual diminution of vision in his right eye, for the past 6 months. Ocular examination on presentation revealed a vision of 6/60 in his right eye with no improvement. The vision in his left eye was normal i.e. 6/6. The intraocular pressure (IOP) of the right and left eye, measured using a non-contact tonometer (NCT), was 14 mm of Hg and 13 mm of Hg, respectively. Slit lamp m e d i c a l j o u r n a l a r m e d f o r c e s i n d i a 7 1 (2 0 1 5) 3 8 4-3 8 8
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