However, the Paule-Mandel estimator of tau 2 and Hartung-Knapp-Sidik-Jonkman adjustment that we used account for it. In addition, all the included studies in our study were unblinded and this make them subject to detection, performance, and reporting biases.In patients with ASCVD, using polypill strategy as a substitute to using separate key cardiovascular medications was associated with lower risk for MACE and MI. The use of polypill could be an important strategy to increase the adherence rates in the secondary prevention of ASCVD and improve outcomes.
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