Background: Several plant extracts and herbs have been used for treating and prevention of cardiovascular diseases hypertension, angina pectoris, congestive heart failure, atherosclerosis, cerebral and venous insufficiency and arrhythmia. Similarly, aqueous extracts of Citrus aurantifolia and Zingiber officinale which is commonly called as lemon and ginger respectively and its formulation were analysed for its antioxidant and anti cholesterol activity. Objective: This research has been performed in order to evaluate the anti cholesterol and antioxidant potentiality of aqueous extracts of Citrus aurantifolia, Zingiber officinale and its formulation respectively. Methods: The study setting carried out for this research was in vitro, hence the work was performed outside the living organism. Citrus aurantifolia and Zingiber officinale were purchased from a farm in chennai. The experiment began starting from the preparation of aqueous extract of lemon and ginger. A formulation was made combining equal amounts of the two extracts followed by this, a phytochemical screening test was conducted. Antioxidant and anti cholesterol potential of the extracts and its formulation were also analysed. The data was statistically examined by one-way analysis of variance (ANOVA) continued by Duncan’s multiple range test, it was compiled to see the statistical significance among the groups present. The results carrying p<0.05 level were contemplated to be statistically significant. Result: From the study, though both the extracts possessed a good antioxidant and anti cholesterol potential, comparatively the formulation exhibited an increased antioxidant and anti cholesterol potential respectively (IC₅₀ = 250 µg/ml) and (IC₅₀= 375µg per ml). Here, the formulation exhibited significantly more activity than the individual extracts. Conclusion: Even though there is sufficient knowledge among citizens about the nutritional value present in herbal formulations, there isn’t enough in-depth study conducted on the formulation of these two extracts based on their cholesterol inhibitory activity. From this particular study it was proven that the formulation showed synergism. Hence the formulation of these extracts could be preferred over other synthetic drugs since it is natural, cost effective and easily accessible.
Introduction: Inflammation is said to be the response of the body to an injury. It is a body defence reaction to reduce or eliminate the spread of injurious agents. It is essential that steps should be taken to introduce new medicinal plants and to develop cheaper, effective and safe analgesic and anti-inflammatory drugs. The main aim of this study is to assess the potential anti-inflammatory activity of Tecoma stans, Acalypha indica and Abutilon indicum plant is being studied. Materials and Methods: Protease inhibition assay was done by Bovine serum albumin was added to plant samples with increase in concentrations as per the standard methods. In this study, Aspirin was used as a standard anti-inflammatory drug.The data were analyzed statistically by a one-way analysis of variance (ANOVA) followed by Duncan’s multiple range test to see the statistical significance among the groups. The results with p<0.05 level were considered to be statistically significant. Results: In this study, it was observed that the plant leaf extract of Tecoma stans, Acalypha indica and Abutilon indicus contain anti-inflammatory activity. The protein denaturation inhibitory activity of leaf extract of Tecoma stans, Acalypha indica and Abutilon indicum, plant extract was represented graphically. Tecoma stans, was observed to contain the anti inflammatory activity. Conclusion: This study revealed that Tecoma stans, Acalypha indica and Abutilon indicum are important medicinal plants with diverse pharmacological spectrum and contain anti-inflammatory properties. Hence, this research has been taken to collect and compile the pharmacological uses of these plant extracts which will be useful to the society to venture into a field of alternative systems of medicine.
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