With the escalating
demand for sustainable energy sources, the
sodium-ion batteries (SIBs) appear as a pragmatic option to develop
large energy storage grid applications in contrast to existing lithium-ion
batteries (LIBs) owing to the availability of cheap sodium precursors.
Nevertheless, the commercialization of SIBs has not been carried out
so far due to the inefficacies of present electrode materials, particularly
cathodes. Thus, from a future application perspective, this short
review highlights the intrinsic challenges and corresponding strategies
for the extensively researched layered transition metal oxides, polyanionic
compounds, and Prussian blue analogues. In addition, the commercial
feasibility of existing materials considering relevant parameters
is also discussed. The insights provided in the current review may
serve as an aid in designing efficient cathode materials for state-of-the-art
SIBs.
Continuous processing offers a promising approach to revolutionize biotherapeutics manufacturing as reflected in recent years. The current study offers a comparative economic assessment of batch and continuous processing for the production of biotherapeutic products. Granulocyte-colony stimulating factor (GCSF), a protein
Postoperative malignant hyperthermia (MH) is a very rare phenomena. It is generally observed within less than an hour after discontinuation of the anesthetic trigger. Present case describes rare delayed postoperative presentation of MH after off-pump coronary bypass surgery. Prompt recognition and immediate treatment with dantrolene can effectively treat the fatal syndrome. Family education and genetic counseling should be encouraged.
The pandemic of COVID‐19 has caused enormous fatalities worldwide. Serological assays are important for detection of asymptomatic or mild cases of COVID‐19, and sero‐prevalence and vaccine efficacy studies. Here, we evaluated and compared the performance of seven commercially available enzyme‐linked immunosorbent assay (ELISA)s for detection of anti‐severe acute respiratory syndrome corona virus 2 (SARS‐CoV‐2) immunoglobulin G (IgG). The ELISAs were evaluated with a characterized panel of 100 serum samples from qRT‐PCR confirmed COVID‐19 patients, collected 14 days post onset disease, 100 SARS‐CoV‐2 negative samples and compared the results with that of neutralization assay. Results were analysed by creating the receiver operating characteristic curve of all the assays in reference to the neutralization assay. All kits, were found to be suitable for detection of IgG against SARS‐CoV‐2 with high accuracy. The DiaPro COVID‐19 IgG ELISA showed the highest sensitivity (98%) among the kits. The assays demonstrated high sensitivity and specificity in detecting the IgG antibodies against SARS‐CoV‐2. However, the presence of IgG antibodies does not always correspond to neutralizing antibodies. Due to their good accuracy indices, these assays can also aid in tracing mild infections, in cohort studies and in pre‐vaccine evaluations.
In December of 2019, the first outbreak of COVID-19 was detected in mainland China, eventually spreading to every continent in the world except Antarctica. Named Coronavirus Disease 19 by the World Health Organization (WHO), this highly contagious disease was caused by the virus SARS-CoV-2. With a transmission rate greater than SARS or common flu, continued tremendous efforts will be needed to successfully combat this disease. In this article, we review the role that data science is playing in this war. Data science, combined with statistical analysis, computer science and computational biology, is helping in myriad ways with applications including epidemiology, drug discovery, and molecular design for diagnostic and therapeutic purposes. A number of data driven models, mathematical models, correlations and predictive models have been developed for COVID-19. Challenges faced by the data scientists today have been highlighted. Finally, open source datasets sources are mentioned that can be potentially used in diagnostics and evaluation of health policies.
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