Malignant Nodular hidradenoma is an extremely rare aggressive tumour originating from eccrine sweat glands with an incidence of <.001%. So far less than 80 cases have been reported in the literature. It’s known for its local recurrence (50%) and metastasis (60%) and hence early diagnosis and radical treatment is mandatory. But differentiating it from its benign counterparts and other skin tumour mimics is challenging, due to its histopathological similarity & lack of diagnostic immunomarkers. Authors report a case of 65-year-old female who presented with a short 4-month history of rapidly growing ulceroproliferative growth in the right inguinal region with bilateral inguinal node enlargement, associated with pain and discharge. Wedge biopsy of left inguinal lymph node showed malignant cutaneous adnexal tumour deposits, which after excision was typed as malignant nodular hidradenoma. It was confirmed with immunohistochemistry. Patient presented with recurrence 8 months after excision.

No abstract

Introduction: Thyroid disorders are common in the reproductive age group of women and these can cause significant perinatal outcomes.Though the effect of abnormal thyroid hormones on the foetus and its development is established, their effect on the placenta and its contribution towards the effect is not elaborately studied. Aim: To compare the microscopic features of euthyroid placentae with those of mothers with thyroid dysfunction. Materials and Methods: This is prospective observational study wherein placentae received from October 1 ,2017 to March 31, 2019 in the Department of pathology, Karnataka Institute of Medical Sciences, Hubballi, Karnataka, India, were collected, processed and analysed. A total of 539 cases were received for histopathological examination during this period, of these 64 cases had abnormal antenatal thyroid profile. These were compared grossly and microscopically with the control group of 64 euthyroid cases. Results: The total sample of the study comprised of case group(n=64) and control group(n=64), mean age: mean age of the women 26.91±4.1 years. The case group samples included 3 hyperthyroid cases and 61 hypothyroid cases.In the control group, 3 (2.3%) foetuses were dead as compared to 6 (4.7%) foetuses in hypothyroid group and 3 (2.3% of total, 100% of hyperthyroid group) foetuses in hyperthyroid group (p< 0.001). Abnormal shape of the placenta was seen in 1 (0.8%) case in normal group as compared to 3 (2.3%) in hypothyroid group and 1 (0.8%) case in hyperthyroid group (p=0.018). However, there weren’t any significant microscopic changes. Conclusions: Maternal thyroid disorders result in abnormal shape of placenta and hence resulting in foeto-maternal insufficiency and subsequent foetal growth restriction and adverse foetal outcome.

Foetal and Perinatal Autopsy-A Study Of 100 Cases Autopsy examination of the foetus or neonate was performed after obtaining informed written consent from parents or the guardian explaining the procedure and the utility of the outcome. All autopsies were performed by the pathologist. Each foetus was examined according to a predetermined protocol which included clinical and ultrasound diagnosis, photographs, Multiple X rays, anthropometry, external and internal examination. The thoracic, cervical, abdominal and pelvic organs were removed en bloc and subsequently

Background: Salivary gland neoplasms account for 2–6.5% of all the head and neck tumours, and fine needle aspiration cytology (FNAC) is a relatively faster diagnostic method which aids the clinicians to decide the initial line of management. This study was undertaken to evaluate the various cytomorphological features of salivary gland lesions by FNAC. This prospective, observational study was done for a period of 12 months from JanuaryMaterials And Methods: 1, 2019 to January 1, 2020 at a tertiary care centre. A total of 127 FNAC were included in this study. The lesions were evaluated cytologically after staining and then correlated clinically and radiologically. Out of the 127 casesResults: studied, most common age group involved was adults between 31–40 years (18.1). The youngest patient was 3 years of age and the oldest was 94 years of age with a Male: Female (M: F) ratio of 1.96:1. The most common site of involvement was the parotid gland with a frequency of 79 (62.2%), the predominant benign lesions diagnosed cytologically were inflammatory lesions and suppurative lesions- 70 (55.11%) cases followed by pleomorphic adenoma of 22 (17.3%) cases., and the most common malignant lesion diagnosed was mucoepidermoid carcinoma, comprising of eight (9.88%) cases. Two cases of Mucoepidermoid Carcinoma were also reported in the age group of 0-20 years. Conclusion: This study describes the various cytomorphological features of salivary gland lesions and demonstrates how they serve as rapid test and aid patient management. Besides with ancillary techniques, the FNAC diagnosis can be as good as confirmatory tests despite being minimally invasive.