Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre-operative SARS-CoV-2 infection were compared with those without previous SARS-CoV-2 infection. The primary outcome measure was 30-day postoperative mortality. Logistic regression models were used to calculate adjusted 30-day mortality rates stratified by time from diagnosis of SARS-CoV-2 infection to surgery. Among 140,231 patients (116 countries), 3127 patients (2.2%) had a pre-operative SARS-CoV-2 diagnosis. Adjusted 30-day mortality in patients without SARS-CoV-2 infection was 1.5% (95%CI 1.4-1.5). In patients with a pre-operative SARS-CoV-2 diagnosis, mortality was increased in patients having surgery within 0-2 weeks, 3-4 weeks and 5-6 weeks of the diagnosis (odds ratio (95%CI) 4.1 (3.3-4.8), 3.9 (2.6-5.1) and 3.6 (2.0-5.2), respectively). Surgery performed ≥ 7 weeks after SARS-CoV-2 diagnosis was associated with a similar mortality risk to baseline (odds ratio (95%CI) 1.5 (0.9-2.1)). After a ≥ 7 week delay in undertaking surgery following SARS-CoV-2 infection, patients with ongoing symptoms had a higher mortality than patients whose symptoms had resolved or who had been asymptomatic (6.0% (95%CI 3.2-8.7) vs. 2.4% (95%CI 1.4-3.4) vs. 1.3% (95%CI 0.6-2.0), respectively). Where possible, surgery should be delayed for at least 7 weeks following SARS-CoV-2 infection. Patients with ongoing symptoms ≥ 7 weeks from diagnosis may benefit from further delay.

SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery); recent (1-6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2; 2.2% (50/2317) in patients with peri-operative SARS-CoV-2; 1.6% (15/953) in patients with recent SARS-CoV-2; and 1.0% (11/1148) in patients with previous SARS-CoV-2. After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1-2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2-3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9-3.0)). Overall, venous thromboembolism was independently associated with 30-day mortality ). In patients with SARS-CoV-2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri-operative or recent SARS-CoV-2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS-CoV-2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly.

Background: Post-term pregnancies are associated with significant foetal morbidity and increase in interventions which jeopardise the health of the fetus as well as the mother. The objective of this study was to determine the incidence, risk factors, maternal and foetal outcomes of such pregnancies.Methods: A retrospective study of 117 post-term pregnancies was studied over a period of one year, January to December 2016. Age, parity, amniotic fluid index, color of liquor, mode of delivery, maternal and foetal outcomes were studied in detail and analysed.Results: There were 10390 deliveries during our study period. 130 among them were post-term, 117 were included in the study, amounting to an incidence of 1.12%. Post-term pregnancy was noted to be higher in women of age group 21-25years (68.5%) and among primigravidae (51.2%). 66 women experienced vaginal delivery (56.4%) and 49 women underwent caesarean delivery (41.8%). Most common indications for caesarean section were foetal distress, oligohydramnios, and foetal growth restriction. NICU admissions were 16 babies and 2 early neonatal deaths were noted.Conclusions: Post-term pregnancy requires early detection, proper planning of pregnancy termination. These women should be offered induction of labour prior to 42 weeks of gestation age to avoid adverse maternal and perinatal outcomes.

Background: Auditing c section rates can be done using Robson’s classification which in turn helps achieve a uniform basis for comparison across centers and across various countries.Methods: A retrospective analysis was done in a tertiary care hospital in north Karnataka KIMS, over a period of 6 months May 2017 to October 2017. All cases of LSCS done during this period were classified according to Robson’s classification and analyzed.Results: Out of 5080 overall deliveries 1876 delivered by cesarean section attributing to 36.76% cesarean section rate. Highest contribution was from group 5 (36%) and group 2 (19.24%).Conclusions: Robson’s classification helps to identify and analyze the group that contribute to the most to overall cesarean section rate and this helps us to modify strategies and interventions to optimize cesarean section rate.

Background: India has the third largest population of HIV. Moving from single dose nevirapine in labor to use of HAART treatment for all pregnant women and the outcome of the same was the subject of present study.Methods: Retrospective study of HIV positive pregnant women on HAART treatment admitted in labor room at Karnataka institute of medical sciences from June 2015 to December 2016. A retrospective analytical study of 93 women with HIV positive status on HAART therapy admitted in labor at KIMS was done by collecting data from case records. Baby follow up details were collected from ART center, KIMS.Results: Parameters studied were maternal and fetal outcomes. Maternal outcome in terms of mode of delivery, morbidity and mortality and fetal outcomes in terms of APGAR at birth, weight of the baby, NICU admission, incidence of meconium, still birth and intrauterine fetal demise, follow up of the babies at 6 weeks, 6 Months and 18 Months for seropositivity.Conclusions: HAART in pregnant women significantly improved the maternal and fetal outcomes.