As selective serotonin re‐uptake inhibitors (SSRIs) are commonly prescribed, less common side‐effects such as severe adverse cutaneous drug reactions (ACDRs) can be seen more frequently than with less frequently prescribed antidepressants. Sertraline is among the better tolerated SSRIs. Here, we describe a case of a sertraline‐induced severe ACDR in a patient with depressive symptoms and cognitive impairment. The selection of an appropriate antidepressant proved challenging. A review of recent literature on the clinical and temporal presentation of SSRI‐induced ACDRs is presented with management strategies.
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