not interfere and even sharpened the color change slightly when present in amounts of between 10 and 50% of the total solution volume. However, the presence of any base such as ammonia or amines, which might be used to decompose the Grignard complex formed in the preparation of the ketimines, interfered with the analysis. A new
We report the first application of oscillatory shear rheology to study phase behavior of IgG2 in a sucrose-containing formulation and its correspondence with physical stability not explained by glass transition (Tg'). We provide a mechanism and data suggesting that protein instability occurs at the ice/water interface.
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