RESUMOOs ácidos graxos são substâncias que fazem parte da constituição das moléculas de lipídeos e podem ser classificados segundo a sua estrutura química em ácidos graxos saturados e insaturados. A ingestão de lipídeos na dieta constitui atualmente em um dos fatores de risco para o desenvolvimento de doenças cardiovasculares, classificadas como a principal causa de morte nos dias de hoje. Dietas ricas em ácidos graxos saturados e insaturados trans são responsáveis pelo desenvolvimento de hipercolesterolemia, por isso o consumo está relacionado ao aumento do risco de desenvolvimento de doenças cardiovasculares. As pesquisas envolvendo ácidos graxos insaturados da série ω-3, mostram que em humanos, os ácidos graxos desta classe promovem efeitos cardioprotetores envolvendo menor processo inflamatório, prevenção à arritmias, vasodilatação e controle nos níveis de lipídeos no sangue. Portanto, o objetivo deste artigo é apresentar uma visão geral a respeito dos ácidos graxos e seus efeitos sobre o sistema cardiovascular. PALAVRAS-CHAVE: antiarrítmico, coração, deslipidemias, lipídeos, ômega-3 FATTY ACID AND CARDIOVASCULAR SYSTEM ABSTRACT Fatty acids are substances that are part of the constitution of lipid molecules and can be classified according to their chemical structure in saturated and unsaturated fatty acids. The ingestion of lipids represent one of the risk factors for developement of cardiovascular disease, classified as a major cause of death nowadays. Diets rich in saturated and trans-unsaturated fatty acids are responsible for the development of hypercholesterolemia, so their consumption is associated with an increased risk of developing cardiovascular diseases. Research involving unsaturated fatty acids of the ω-3 series, show that in humans, the fatty acids of this class promote cardioprotective effects by decreasing inflammatory process, preventing of
Myxomatous mitral valve disease (MMVD) is characterized by thickening of the valve leaflets and omega-3 (ω-3) supplementation has been associated with modulation of blood pressure (BP) and heart rate, improvement of doppler echocardiographic indices, antiarrhythmic, anti-inflammatory and anti-dislipidemic effects in dogs and humans, although prospective studies of it single use are still absent in the veterinary literature. The objective of this study was to evaluate the influence of ω-3 supplementation in dogs with MMVD. Twenty-nine dogs were followed quarterly for 12 months by clinical evaluation, arterial blood pressure, electrocardiography, doppler echocardiography, thoracic radiography and laboratory tests including inflammatory mediators and cardiac biomarker blood concentrations. The dogs were classified in stages B2 and C, according to the classification proposed by ACVIM 2019. They were randomly assigned to either ω-3 group (ω-3G) or control group (CG). The ingestion of ω-3 reduced the chance of developing arrhythmias by 2.96 times (p = 0.003). The vertebral heart size (VHS) measurements were higher in the control group (p = 0.033). In conclusion, at the dosages used in this study, ω-3 dietary supplementation reduces the volumetric overload, has antiarrhythmic effect and keeps dogs with B2 and C stages of MMVD in milder stages of the disease.
Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.