Hydrogen sulfide (HS) is a mediator of a number of cellular processes, and modulating cellular levels of this gas has emerged as an important therapeutic area. Localized generation of HS is thus very useful but highly challenging. Here, we report pivaloyloxymethyl-based carbonothioates and carbamothioates that are activated by the enzyme, esterase, to generate carbonyl sulfide (COS), which is hydrolyzed to HS.

A vinyl boronate ester-based persulfidating agent that is selectively activated by hydrogen peroxide, which is a reactive oxygen species (ROS), and efficiently generated a persulfide by a hitherto unexplored 1,4-O,S-relay mechanism is reported. This donor was found to protect cells from cytotoxicity induced by oxidants, and the major byproduct is cinnamaldehyde, which is widely used in the food industry as an additive.Letter pubs.acs.org/OrgLett

Reactive sulfur species (RSS) are integral to cellular survival and growth. Here, small molecule generators of RSS are reviewed.

No abstract

Sulfane sulfur species such as persulfides and polysulfides along with hydrogen sulfide protect cells from oxidative stress and are key members of the cellular antioxidant pool. Here, we report perthiocarbamate-based...

Persulfides and polysulfides, collectively known as the sulfane sulfur pool along with hydrogen sulfide (H2S), play a central role in cellular physiology and disease. Exogenously enhancing these species in cells...

A highly stereo‐ and regioselective, metal‐free intramolecular epoxide‐arene cyclization of 2‐(phenoxymethyl)‐3‐aryloxiranes yields trans‐4‐arylchroman‐3‐ols in moderate to high yields.

Mythological retellings have explored those issues of the epics which were submerged in the objective representation of the events. Redefining the existence of the epical characters, these revisionist writings have presented the events from the alternate perspectives. With an attempt to deconstruct the concept of ‘truth’, the contemporary mythological retellings have tried to demystify the dominant ideologies, and for this purpose they had brought into forefront the overlooked characters. In the grand narrative of the epics like the Ramayana and the Mahabharata the perspectives of the women characters were often overlooked; at the same time the objective representation of the events could not provide the necessary space to delve deep into their psyche. Therefore, ample numbers of the contemporary mythological retellings have highlighted the lives of the women characters of the epics, by presenting the events from their perspectives to explore those facets of the ‘truth’ which were overlooked in the source texts. This research article has attempted to reconstruct the identity of Draupadi of the Mahabharata by focusing on her character as depicted by Chitra Banerjee Divakaruni in her The Palace of Illusions, a wonderful mythological fiction reinterpreting the events of the epic Mahabharata from Draupadi’s perspective. Adopting a feminist stance, this research article has explored Draupadi’s resistance to patriarchal domination, and in this way, here an attempt has been undertaken to reassert her individuality and to redetermine her role in the epic.