Three new flavanols, (2R,3S)-7-methoxy-flavan-3-ol (1), (2R,3S)-7-hydroxy-flavan-3-ol (2), and (2R,3S)-2′-hydroxy-7-methoxy-flavan-3-ol (3), together with two known flavans (4 and 5), were isolated from the chloroform extract of Crinum asiaticum. Their structures were elucidated by various spectroscopic methods, including 1D and 2D NMR, HR-ESI-MS, and CD data. The isolated compounds 1 and 3−5 showed inhibitory activity toward LPS-induced nitric oxide (NO) production. Further investigation of the NF-κB pathway mechanisms indicated that 1 and 3−5 inhibited the LPS-induced IL-6 production and p65 subunit phosphorylation of NF-κB in RAW264.7 cells, with an effective dose of 10 µM.
COVID-19 has affected almost everyone on this world directly or indirectly. The virus has changed people's way of life, the economy has collapsed, and because of the effects of the virus, people have maintained social distance. Researchers and scientists around the world are trying their best to find a medication/solution for this disease, and as a result, more than 20,000 research papers have been published during mid-2020. It is a record in itself that in a short period of time. This study was conducted to quantify the Indian researcher's contribution to the COVID-19. Indian authors published a total of 2826 papers, of them 241 were published in single authorship. All these papers were counted 11491 total citations with 4.07 CPP. This study also analysed the research papers using various indicators like country collaborations, author collaborations, authorship patterns, keyword occurrences, etc.
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