Introduction Fibro-osseous lesions are a diverse group of bone disorders and include developmental, reactive or dysplastic diseases and neoplasms. They share overlapping clinical, radiographic and histopathologic features and demonstrate a wide range of biological behaviour.
<p class="abstract"><strong>Background:</strong> The objective of the present study was to analyze the outcome of clinically node-negative early oral tongue cancer after selective neck dissection (SND) versus conventional neck dissection (CND).</p><p class="abstract"><strong>Methods:</strong> A total of 116 patients of early oral tongue cancer underwent neck dissection either SND or CND between 1<sup>st</sup> January 2013 to 31<sup>st</sup> December 2016 at Government Royapettah Hospital, Chennai, a tertiary level cancer center. For patients with pN0 after SND had no further procedure while for those with cN1 disease, CND was done as a standard procedure. Comparison between the cN0 nodes to pN1 conversion rates in SND group with cN1 to pN0 rates in CND group was done along with the morbidity rates. The clinicopathological parameters along with intraoperative and postoperative parameter relevant to recurrence were analyzed by univariant and multivariant analysis and both the groups were compared by Chi-square test (SPSS version 26.0). </p><p class="abstract"><strong>Results:</strong> In the SND group, pN1 were 2/53 (3.77%) and in the CND group pN1 was 11/63 (17.46%). Mean Nodal retrieval in SND group was 18.96 nodes and in CND group 22.90 nodes per case. Regional nodal recurrences in the SND group were 8/53 (15.81%) and in the CND group was 9/63 (14.28%). Our study shows no significant statistical difference between nodal recurrences in CND and SND group.</p><p><strong>Conclusions:</strong> Our study data suggests that for cN1 patients, SND may be optimal and early tongue cancer patients with cN0 could be candidates for an SND instead of CND.</p>
Background: The MAGIC and ACCORD 07 trials have established the role of perioperative chemotherapy in locally advanced gastric adenocarcinoma. A more recent study has demonstrated the superiority of the FLOT perioperative regimen. The best strategy to improve outcomes has yet to be determined. Aims of the study were to evaluate perioperative chemotherapy in terms of morbidity and tolerance of FLOT regimen with modification and histopathological responseMethods: This prospective study was started after ethical committee approval in February 2019 at a tertiary cancer center in South India for a period of 1 year up till February 2020. Patients fulfilling inclusion criteria were enrolled. Perioperative chemotherapy was given as scheduled regimen and adverse effects and response to preoperative chemotherapy were recorded. Radical D2 gastrectomy and histopathology assessed analysed by using IBM SPSS statistics ver. 21 and descriptive statistics used.Results: From February 2019 till February 2020, a total of 24 patients of newly diagnosed adenocarcinoma of the stomach of which 18 patients were nonmetastatic on workup. Moderately different (38.8%), well-differentiated in 11.2%, poorly differentiated in 50%. Total 66.7% were diagnosed as metastatic on staging laparoscopy, peritoneal wash cytology in 50% was negative. The cardiopulmonary resuscitation was seen in two patients.Conclusions: Even though it is an interim analysis with less number of patients enrolled, so far it can be concluded that all patients where surgery is planned should undergo peritoneal lavage cytology and FLOT regimen can be practised with acceptable morbidity. Long term results after completion of study will definitely throw more light.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.