Canalicular adenoma is a benign neoplasm of salivary gland. We are presenting a case in a 19 year old lady as a swelling in the floor of mouth which presents as a painful lesion. Histopathologically it is a single lobular lesion which shows luminal columnar cells arranged in canalicular pattern. No evidence of malignant transformation and the mode of presentation signify this publication.
Lipomas are benign, mesenchymal neoplasms occurring in areas of abundant adipose tissue. 1 They can be found anywhere in the body with approximately 15-20% located in the head and neck region and the majority of it rest on the shoulder and back. 2 They are not very common in the hand and those involving the fingers are extremely rare, with reported incidence of 1%. The first person to report a case of lipoma of the finger was Stein in 1959 3 and since then, 14 cases were identified in the literature. 4 Of those, 3 cases were on the index finger, 2 cases distal to the right proximal inter phalangeal joint 5 and 1 case to the left index finger. 6 All of them were post traumatic in nature. In this report, we present a forty one year old male, with lipoma of the right ring finger.
Human papillomavirus (HPV) is an epitheliotropic virus that can infect and cause disease of skin or mucosa at any site. HPV associated lesions can be broadly divided into cutaneous and mucous membrane lesions. Cutaneous lesions include: warts, Butcher's wart and epidermodysplasia verruciformis. The anogenital diseases, include warts (condyloma), dysplasia (cervical, vaginal, vulvar, anal), and squamous cell carcinoma. Here we are presenting a case report of a 27 year old female who was histologically diagnosed as inverted condyloma a rare condylomatous lesion involving the uterine cervix. KEYWORDS: Inverted Condyloma, uterine cervix. INTRODUCTION:Independent of the site or the type of lesion, the papilloma virus virion has a constant morphology and structure. 1 The virion is a non-enveloped 8 Kb long icosahedral structure of 55-60 nm diameter, which forms paracrystalline arrays in the nucleus of infected cells. 2 Epidemiologic studies show genital warts to be among the most common sexually transmitted diseases, after chlamydia and gonorrhea. The incidence of condyloma acuminatum has been steadily rising over the past three decades. 3 W.H.O. estimates that 630 million people are infected with genital HPV, resulting in a worldwide prevalence of 9-13%. 4 There is an inverse relationship between age and HPV prevalence in many countries. In some countries, cross-sectional and cohort studies have shown a U-shaped curve with a first peak in women under 30 years of age and a second peak in women aged 55-64 years. 5 It is believed that many sexually active adults are infected with HPV, but only 1±2% of them are found to have clinical lesions. Rest of the infections remain subclinical, with the latent HPV residing in the epithelial basal cells. 6 The most important risk factor for genital warts are decreasing age of first sexual intercourse, multiple sexual partners and clinical history of other venereal diseases. 7
A 50 year old female presented with complaints of asymptomatic, raised skin lesion over left leg for the past two years, which on local examination revealed a single, localized, well defined, rounded plaque of 4 cm. Clinically Bowen's disease was not suspected because of its rarity and also occurred in the unusual site. Biopsy was taken and sent for histo-pathological examination. In histopathological examination Bowen's disease was diagnosed. This case is highlighted to show the pathologist's help in making a proper diagnosis when atypical skin lesions are seen at unusual sites. INTRODUCTION: Most of the overt malignant conditions actually originate as microscopic lesions, which are designated as in-situ carcinomas. These in-situ carcinomas are typically noticed as intraepithelial lesions, most often seen in squamous cell epithelial lined tissue eg. oral mucosa, genitals, cervix and skin. In skin, the intra-epithelial carcinoma-in situ lesions may be Bowen's disease, Bowenoid papulosis or Erythroplasia of Queyrat. In the same way gastrointestinal and urinary system also can show in-situ malignancies. Bowen's disease was first described by an American dermatologist John T Bowen in the year 1912. It is most commonly reported in sun exposed sites. It rarely occurs in patients with darkly pigmented skin. Bowen's disease is observed in skin and external genitals and is sometimes associated with arsenic poisoning and visceral carcinomas. Bowen's disease is a rare, persistent, progressive, intra-epithelial carcinoma, 8% of which will develop into an invasive squamous cell carcinoma. Treatment options are topical 5-fluorouracil, cryotherapy or surgical excision. Further a detailed clinical examination is needed along with supportive diagnostic aids to exclude the possibility of any internal malignancy. A wide excision is to be done to prevent invasive malignant tumor.
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