Introduction: Methotrexate, a folate antimetabolite, immunosuppressant and cytotoxic chemotherapeutic agents employed for malignant conditions. Continuous exposure of methotrexate produces adverse side effects especially liver toxicity. Recently, medicinal plants are gaining an importance owing to their phytoconstituents which are responsible for their medicinal value. Capparis decidua is one such medicinal plant widely used in the traditional system of medicine. No study has focused the mechanism of hepatoprotective property of Capparis decidua via Nrf2/HO-1 and PPARγ signaling pathway. Hence the study was mainly focused on its ability to modulate Nrf2 and PPARγ signaling in the methotrexate induced hepatotoxicity in Wistar rats. Materials and Methods: 30 female Wistar albino rats were divided into five groups. Following a single dose of methotrexate (20 mg/kg, intraperitoneally) injection, Wistar rats were orally administered with Capparis decidua at a doses of 250 mg/kg and 500mg/kg for 14 days. AST, ALT and ALP, antioxidants like GST, GPx, GR, were assessed in hepatic tissue. LPO, H 2 O 2 , OH radicals were assessed. mRNA expression of Nrf2, HO-1, PPARү was carried using real-time PCR in hepatic tissue. Nrf2, TNF-α, IL-1β proteins were assessed using western blot. Results: Methotrexate administration significantly increased liver function marker, caused lipid peroxidation and decreased antioxidants levels. Treatment with Capparis decidua caused significant decrease in AST, ALT, ALP, levels and significant increase in GST, GPx, GR. Methotrexate decreased mRNA expression of Nrf2, HO-1, PPARγ. Capparis decidua prevented methotrexate induced liver injury by upregulating Nrf2 and PPARү signaling pathway. Capparis decidua also suppressed inflammatory markers like TNF-α and IL-1β proteins. Conclusion: Capparis decidua has thus attenuated methotrexate induced hepatotoxicity and this could be via up-regulation of Nrf2/HO-1 and PPARγ pathways.

Objectives Coronavirus disease is an infectious disease caused by a newly discovered coronavirus. This virus primarily spreads through droplets of saliva or discharge from the nose when an infected person coughs or sneezes. This virus was named after its shape, which takes the form of a crown with protrusions around it. The World Health Organization has recommended personal protective equipments (PPE) to doctors and health care workers attending COVID-19 patients. PPE generally includes masks, goggles, respirators, gloves, face shields, and isolation gowns. The principle aim of this study is to create awareness among dental students about the preventive measures taken by health care professionals while attending patients affected with COVID-19. Materials & Methods A questionnaire comprising 15 questions was created using an online Google forms website and was circulated among 100 dental students. The survey was conducted within a week in the months of April to May 2020. The results and observations were recorded in the form of pie charts. Results Ninety-three percent of the participants have stated that health care professionals must clean their hands often, cover their nose and mouth, and maintain safe distance from everyone in order to prevent the virus from affecting them. Sixty-three percent of the participants are familiar with the term PPE. Majority assume that health care professionals are given enough safety precautions while treating a patient with coronavirus. Conclusion Hence, to conclude, health care professionals play a vital role in improving access and quality health care for the population, and hence, they must be protected as well. Since dental students treat patients, they are vulnerable to infection as well, and must take proper safety measures.

Alzheimer's Disease (AD) is one of the most common causes of dementia, mostly affecting the elderly population. Currently, there is no proper diagnostic tool or method available for the detection of AD. The present study used two distinct data sets of AD genes, which could be potential biomarkers in the diagnosis. The differentially expressed genes (DEGs) curated from both datasets were used for machine learning classification, tissue expression annotation and co-expression analysis. Further, CNPY3, GPR84, HIST1H2AB, HIST1H2AE, IFNAR1, LMO3, MYO18A, N4BP2L1, PML, SLC4A4, ST8SIA4, TLE1 and N4BP2L1 were identified as highly significant DEGs and exhibited co-expression with other query genes. Moreover, a tissue expression study found that these genes are also expressed in the brain tissue. In addition to the earlier studies for marker gene identification, we have considered a different set of machine learning classifiers to improve the accuracy rate from the analysis. Amongst all the six classification algorithms, J48 emerged as the best classifier, which could be used for differentiating healthy and diseased samples. SMO/SVM and Logit Boost further followed J48 to achieve the classification accuracy.

Stress is a feeling of emotional or physical tension. It can be triggered by any event or thought that causes you to feel dissatisfied, angry, or anxious. The body’s response to a challenge or demand is known as stress. The importance of developing cost-effective stress reduction interventions is high due to the difficulty of reducing or preventing stress without professional help and the large demand for non-pharmacological stress reduction interventions. Music therapy is the clinical application of musical therapies to improve a client’s quality of life based on scientific evidence. Music therapists use both active and receptive music experiences to help clients improve their health in cognitive, motor, emotional, communicative, social, sensory, and educational domains by using music and its many facets, which include physical, emotional, mental, social, aesthetic, and spiritual domains. Nowadays, stress is increasingly widespread among all individuals all over the world, and people are more aware of it than ever before. This chapter may assist the general public in gaining a broad understanding of the role of music therapy in stress management, as well as assisting individuals in self-recovery.

Inflammatory is cascade process triggered by pro-inflammatory cytokines and anti-inflammatory. In the present study anti-inflammatory activity of Stachydrine and Sakuranetin were studied against the inflammatory target proteins IL-6 and TNF-α by using molecular docking analysis. Both compounds showed the good binding with selected target proteins. Compared to Sakuranetin, the Stachydrine have lowest binding energy and good hydrogen bond interactions. Hence results of study indicated that Stachydrine possessed high and specific inhibitory activity on tumor necrosis factor-α and interleukin-6.