The medicinal reputation of Ganoderma lucidum and its unique pharmaceutical and nutritional properties have led to its demand as an important resource for nutrient supplements in the food industry.
Bi2MoO6 (BMO) nanoparticles (NPs)
have been
widely used as a photocatalyst to decompose organic pollutants, but
their potential for photodynamic therapy (PDT) is yet to be explored.
Normally, the UV absorption property of BMO NPs is not suitable for
clinical application because the penetration depth of the UV light
is too small. To overcome this limitation, we rationally designed
a novel nanocomposite based on Bi2MoO6/MoS2/AuNRs (BMO-MSA), which simultaneously possesses both the
high photodynamic ability and POD-like activity under NIR-II light
irradiation. Additionally, it has excellent photothermal stability
with good photothermal conversion efficiency. The as-prepared BMO-MSA
nanocomposite could induce the germline apoptosis of Caenorhabditis elegans (C. elegans) via the cep-1/p53 pathway after being illuminated
by light with a wavelength of 1064 nm. The in vivo investigations confirmed the ability of the BMO-MSA nanocomposite
for the induction of DNA damage in the worms, and the mechanism was
approved by determining the egl-1 fold induction
in the mutants that have a loss of function in the genes involved
in DNA damage response mutants. Thus, this work has not only provided
a novel PDT agent, which may be used for PDT in the NIR-II region,
but also introduced a new approach to therapy, taking advantage of
both PDT and CDT effects.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.