Light energy can be considered as an ideal eco-friendly source of energy for green chemistry. This perspective
was used to synthesize 5-aryl-1,2,4-thiazolidine-3-thiones derivative as a quick, efficient and highly improved protocol. The
present method developed as energy competent and integrated technique by one-pot condensations of aromatic aldehyde
and thiosemicarbazide under the catalyst-free condition in aqueous-alcoholic media. The impact of light on reaction along
with mechanical stirring provided a prominent yield of the product. The mild reaction conditions, short reaction time and
easy workup procedure, avoidance of heavy metal catalyst and harsh reaction conditions make this protocol greener
A new series of novel synthesis of bis(2-(substituted(methyl)amino)-4-phenylthiazol-5-yl)methanone
(PVS 1-9) is reported. The carbonyl isothiocyanate (3) was synthesized by a para-cleavage of C–Cl
bond of benzoyl chloride (1) with ammonium thiocyanate (2). The presence of carbonyl group in acyl
isothiocyanates enhance the reactivity of acyl isothiocyanates upon reaction with substituted secondary
amine (4) give n-alkylated adduct (5), which upon the reaction with dichloro acetone give target
compound 7. Substituted derivatives as inhibitors against lungs, breast and EJFR assist cancer based
on virtual screening cellular evaluations with NSCLC H1975 harboring EGFR L858R/T790M double
mutations indicated that the most active compound PVS-7 could inhibit the proliferation of two cell
lines in one digital micromolar scale. The enzymatically results indicated that compounds PVS-2,
PVS-4 and PVS-9 were the most active inhibitor against EGFR T790M and above cancer activity
with a ~82%. All compounds were well characterized by spectroscopic techniques and their purity
was confirmed by UV-HPLC.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.