ABO and Rh blood group systems are the most important blood grouping systems from clinical aspect. Determination of blood group is important for blood transfusion therapy, medico-legal purposes, organ transplantation, settlement of paternity disputes etc. Nearly 25 types of blood groups are present. ABO incompatibility between mother and fetus may produce infertility or hemolytic disease of the new born, and persons of certain blood groups have an increased susceptibility to peptic ulcer or gastric cancer. The purpose of this review is to summarize the concepts and origin of ABO and other blood groups systems and Chemistry of Blood group specificity (Glycoproteins found in body fluids).
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