Novel strategies focused towards targeting drug substances specifically to brain tumor site would increase the therapeutic efficiency and reduce the toxicity of chemotherapeutics.
High performance liquid chromatography (HPLC) analysis of both the drugs i.e. Minoxidil and Tretinoin was carried out in methanol and phosphate buffer pH 7.4 using Agilent HPLC system. A stock solution of 100µg/ml for both the drugs was prepared in methanol and phosphate buffer pH 7.4 and from this stock solution different dilutions were prepared to plot a calibration curve between area and concentration. The different parameters for HPLC analysis of both the drugs are indicated in Table 1.
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