The COVID-19 pandemic presented enormous data challenges in the United States. Policy makers, epidemiological modelers, and health researchers all require up-to-date data on the pandemic and relevant public behavior, ideally at fine spatial and temporal resolution. The COVIDcast API is our attempt to fill this need: Operational since April 2020, it provides open access to both traditional public health surveillance signals (cases, deaths, and hospitalizations) and many auxiliary indicators of COVID-19 activity, such as signals extracted from deidentified medical claims data, massive online surveys, cell phone mobility data, and internet search trends. These are available at a fine geographic resolution (mostly at the county level) and are updated daily. The COVIDcast API also tracks all revisions to historical data, allowing modelers to account for the frequent revisions and backfill that are common for many public health data sources. All of the data are available in a common format through the API and accompanying R and Python software packages. This paper describes the data sources and signals, and provides examples demonstrating that the auxiliary signals in the COVIDcast API present information relevant to tracking COVID activity, augmenting traditional public health reporting and empowering research and decision-making.

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The COVID-19 pandemic presented enormous data challenges in the United States. Policy makers, epidemiological modelers, and health researchers all require up-to-date data on the pandemic and relevant public behavior, ideally at fine spatial and temporal resolution. The COVIDcast API is our attempt to fill this need: operational since April 2020, it provides open access to both traditional public health surveillance signals (cases, deaths, and hospitalizations) and many auxiliary indicators of COVID- 19 activity, such as signals extracted from de-identified medical claims data, massive online surveys, cell phone mobility data, and internet search trends. These are available at a fine geographic resolution (mostly at the county level) and are updated daily. The COVIDcast API also tracks all revisions to historical data, allowing modelers to account for the frequent revisions and backfill that are common for many public health data sources. All of the data is available in a common format through the API and accompanying R and Python software packages. This paper describes the data sources and signals, and provides examples demonstrating that the auxiliary signals in the COVIDcast API present information relevant to tracking COVID activity, augmenting traditional public health reporting and empowering research and decision-making.

Unfolding is an ill-posed inverse problem in particle physics aiming to infer a true particle-level spectrum from smeared detector-level data. For computational and practical reasons, these spaces are typically discretized using histograms, and the smearing is modeled through a response matrix corresponding to a discretized smearing kernel of the particle detector. This response matrix depends on the unknown shape of the true spectrum, leading to a fundamental systematic uncertainty in the unfolding problem. To handle the ill-posed nature of the problem, common approaches regularize the problem either directly via methods such as Tikhonov regularization, or implicitly by using wide-bins in the true space that match the resolution of the detector. Unfortunately, both of these methods lead to a non-trivial bias in the unfolded estimator, thereby hampering frequentist coverage guarantees for confidence intervals constructed from these methods. We propose two new approaches to addressing the bias in the wide-bin setting through methods called One-at-a-time Strict Bounds (OSB) and Prior-Optimized (PO) intervals. The OSB intervals are a bin-wise modification of an existing guaranteed-coverage procedure, while the PO intervals are based on a decision-theoretic view of the problem. Importantly, both approaches provide well-calibrated frequentist confidence intervals even in constrained and rank-deficient settings. These methods are built upon a more general answer to the wide-bin bias problem, involving unfolding with fine bins first, followed by constructing confidence intervals for linear functionals of the fine-bin counts. We test and compare these methods to other available methodologies in a wide-bin deconvolution example and a realistic particle physics simulation of unfolding a steeply falling particle spectrum.

This has been one long and arduous journey, but nevertheless a worthwhile life experience because of the many great Professors at SJSU and beloved friends. I am grateful and take this opportunity to thank my advisor Dr. Wu, who has been my constant support not only during the thesis but during my whole master's degree. It wouldn't have been possible without his trust and belief in me to do good research. I also want to thank Dr. Potika and Dr. Orang for consenting to be on my committee and giving their valuable inputs to my project, without which the project would not have been successful. I would also like to thank my parents, my sister Priya and my beloved friend Shweta for supporting and encouraging me throughout my graduation.