Reactive oxygen species (ROS) is considered a double-edged
sword.
The slightly elevated level of ROS helps in wound healing by inhibiting
microbial infection. In contrast, excessive ROS levels in the wound
site show deleterious effects on wound healing by extending the inflammation
phase. Understanding the ROS-mediated molecular and biomolecular mechanisms
and their effect on cellular homeostasis and inflammation thus substantially
improves the possibility of exogenously augmenting and manipulating
wound healing with the emerging antioxidant therapeutics. This review
comprehensively delves into the relationship between ROS and critical
phases of wound healing and the processes underpinning antioxidant
therapies. The manuscript also discusses cutting-edge antioxidant
therapeutics that act via ROS scavenging to enhance chronic wound
healing.
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