Stem cell therapy is a part of regenerative medicine that involves the use of undifferentiated cells in order to cure the disease. Stem cell-based therapies are being investigated for the treatment of many conditions, including neurodegenerative conditions such as Parkinson's disease, cardiovascular disease, liver disease, diabetes, autoimmune diseases and for nerve regeneration. (1) In orofacial region these therapies are being used for tooth and periodontal regeneration, temporomandibular joint reconstruction, alveolar bone regeneration. Craniofacial stem cells including dental pulp derived stem cells have the potential to cure a number of diseases.Present day treatment modalities for oral mucosal lesions like ulcerative lesions, premalignancies and malignancies mainly consist of steroids and antioxidants (which provide only a short term and symptomatic relief) and surgery with or without chemo/radiotherapy (which leave the patient with certain amount of morbidity). Advances in stem cell technology have opened new vistas for treatment of these lesions. Various studies have shown the successful role of stem cell therapies in the treatment of precancerous conditions, oral ulcers, wounds and mucositis. (2) The recent concept of cancer stem cells (CSCs) has directed scientific communities toward a new area of research and possible potential treatment modalities for oral cancer. (3) The present article will discuss the role of stem cell applications in oral mucosal lesions.
Epiglottic cysts are generally benign lesions, which can affect all age groups. Depending on their location and size they can cause airway obstruction and potentially lead to sudden death. I report a case of 45 year old male attended to my clinic with Cyst epiglottis. His complaints were feeling of lump in the throat and occasional attacks of chocking especially during sleep. The patient was successfully treated surgically with no recurrence in the 2years follow-up.
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